RELEASE OF SPECTRIN-FREE SPICULES ON RE-OXYGENATION OF SICKLED ERYTHROCYTES
RELEASE OF SPECTRIN-FREE SPICULES ON RE-OXYGENATION OF SICKLED ERYTHROCYTES
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DOI：
10.1038/295612a0
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发表时间：
1982-01-01
期刊：
影响因子：
64.8
通讯作者：
WESTERMAN, MP
中科院分区：
文献类型：
--
作者：
ALLAN, D;LIMBRICK, AR;WESTERMAN, MP
长期以来，人们一直怀疑镰状细胞病患者的红细胞通过正常的老化过程或由于反复镰状化而逐渐脱落部分质膜，并且这种膜损失可能与不可逆镰状细胞的形成有关1 -3。我们在这里报告，当镰状HbS红细胞通过复氧解除镰状化时，细胞失去102 -3%的脂质，作为杆和微球形式的无血影蛋白的含血红蛋白的针状体。这些仍含有聚合血红蛋白的杆状物最终降解为直径为1.000.1 μm的微泡链。在镰状细胞病患者未经治疗的血液中也发现了类似的针状物质。
It has long been suspected that the erythrocytes of patients with sickle cell disease gradually shed part of their plasma membrane either through a normal ageing process or as a result of repeated sickling, and that this membrane loss may be associated with the formation of irreversibly sickled cells1–3. We report here that when sickled HbS erythrocytes are unsickled by reoxygenation, the cells lose ∼2–3% of their lipid as spectrin-free haeomoglobin-containing spicules in the form of rods and microspheres. The rods, which still contain polymerized haemoglobin, eventually degrade to chains of microvesicles having diameters of ∼0.1 µm. Similar spicular material has been found in the untreated blood of patients with sickle cell disease.