Increased plasma levels of the mature and intermediate forms of adrenomedullin in obesity
Increased plasma levels of the mature and intermediate forms of adrenomedullin in obesity
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DOI：
10.1016/j.regpep.2009.08.003
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发表时间：
2009-11-27
影响因子：
--
通讯作者：
Kitamura, Kazuo
中科院分区：
文献类型：
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作者：
Nomura, Ikuo;Kato, Johji;Kitamura, Kazuo
肾上腺髓质素（AM）是一种心血管保护肽，在包括脂肪组织在内的各种器官和组织中产生。在本研究中，我们通过两种测定方法测量了患有或不患有肥胖症的受试者的血浆AM水平，以分别评估生物活性AM-NH 2和中间形式的AM-甘氨酸（AM-Gly）。我们测量了日本社区52名肥胖和172名非肥胖居民的血浆总AM和AM-NH 2水平，这些居民定期接受健康检查，没有明显的心血管疾病。AM-Gly值通过从总AM中减去AM-NH 2水平获得。肥胖组AM-NH 2和AM-Gly水平均高于非肥胖组，经简单回归分析，体重指数（BMI）与血浆AM-NH 2和AM-Gly水平呈显著相关。此外，多变量分析确定的重要因素是AM-NH 2的BMI和血清甘油三酯，AM-Gly的舒张压，胰岛素，高密度脂蛋白胆固醇和血浆肾素活性。这些结果表明，AM的两种分子形式在与肥胖相关的代谢紊乱中发挥积极作用，而没有明显的心血管疾病。(C)2009爱思唯尔有限公司版权所有。
Adrenomedullin (AM) is a cardiovascular protective peptide produced in various organs and tissues including adipose tissue. In the present study, we measured the plasma AM levels of subjects with or without obesity by two assay methods to separately evaluate the biologically active AM-NH2 and the intermediate form of AM-glycine (AM-Gly). We measured the total AM and AM-NH2 levels of plasma in 52 obese and 172 non-obese residents of a Japanese community, who received regular health check-ups and had no overt cardiovascular disease. AM-Gly values were obtained by subtracting AM-NH2 levels from those of total AM. Both the AM-NH2 and AM-Gly levels of the subjects with obesity were higher than those without obesity, and significant relationships were noted between body mass index (BMI) and the plasma levels of the two molecular forms of AM in a simple regression analysis. Moreover, the significant factors identified by multivariate analyses were BMI and serum triglyceride for AM-NH2 and diastolic blood pressure, insulin, high-density lipoprotein-cholesterol, and plasma renin activity for AM-Gly. These results suggest active roles for the two molecular forms of AM in metabolic disorders associated with obesity in subjects without overt cardiovascular disease. (C) 2009 Elsevier B.V. All rights reserved.