Acute audiogenic stress-induced activation of CRH neurons in the hypothalamic paraventricular nucleus and catecholaminergic neurons in the medulla oblongata
Acute audiogenic stress-induced activation of CRH neurons in the hypothalamic paraventricular nucleus and catecholaminergic neurons in the medulla oblongata
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DOI：
10.1016/s0006-8993(03)02509-5
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发表时间：
2003-06-13
期刊：
影响因子：
2.9
通讯作者：
Palkovits, M
中科院分区：
文献类型：
--
作者：
Helfferich, F;Palkovits, M
短时间听觉刺激（白色噪声）可诱导大鼠脑内几个核团和听皮层神经元细胞c-fos表达增强。通过双重免疫染色，Fos免疫反应阳性细胞核出现在下丘脑室旁核的含促肾上腺皮质激素释放激素（CRH）的神经元中，但在大脑的其他地方，包括中央杏仁核的CRH神经元中没有。在脑中的儿茶酚胺能神经元，只有在延髓细胞（在A1/C1和A2/C2细胞组）建立Fos和酪氨酸羟化酶的双重免疫染色。单侧鼓膜切开并阻塞气道的大鼠，在声刺激下，听通路和听皮层神经元的Fos免疫反应性出现双侧性差异，而下丘脑和杏仁核的Fos免疫反应性则出现双侧性差异。目前的数据提供了证据，CRH合成神经元参与下丘脑和延髓的儿茶酚胺能神经元在中央组织的反应听应激刺激。(C)2003 Elsevier Science B. V.保留所有权利。
Strong c-fos expression was induced in neuronal cells of several brain nuclei and the auditory cortex by a short duration auditory stimulation (white noise) in rats. By double immunostaining, Fos-immunoreactive cell nuclei appeared in corticotropin-releasing hormone (CRH)-containing neurons in the hypothalamic paraventricular nucleus, but not in CRH neurons elsewhere in the brain including the central nucleus of the amygdala. Among brain catecholaminergic neurons, only cells in the medulla oblongata (in the A1/C1 and A2/C2 cell groups) established double immunostaining for Fos and tyrosine hydroxylase. Sound stimulus in rats with unilateral tympanotomy and plugging the airways resulted in side differences of Fos immunoreactivity in neurons of the auditory pathways and the auditory cortex, but the effect was bilateral in hypothalamic and amygdaloid nuclei. The present data provide evidence for the participation of CRH-synthesizing neurons in hypothalamus and medullary catecholaminergic neurons in the central organization of responses to audiogenic stress stimuli. (C) 2003 Elsevier Science B.V. All rights reserved.