Mechanism of potentiation of vascular responses by tetraethylammonium: a novel form of sensitization.
Mechanism of potentiation of vascular responses by tetraethylammonium: a novel form of sensitization.
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四乙铵增强血管反应的机制：一种新型的致敏形式。
DOI：
10.1139/y73-066
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发表时间：
1973
影响因子：
2.1
通讯作者：
S. Kalsner
中科院分区：
文献类型：
--
作者：
S. Kalsner
获得了一种先前未被确认的与钙利用相关的血管平滑肌致敏形式的证据。季铵化合物四乙铵增强了多种激动剂在兔主动脉条中引起的收缩幅度。在用利血平预处理以耗尽内源性儿茶酚胺的兔的主动脉条中，这种增强作用并未减弱。对增强机制的分析表明，四乙铵增加了细胞外和/或松散结合的钙用于收缩的利用。研究发现，在低钙溶液中，增强作用大大减弱，通常被阻断。此外，SKF - 525A这种选择性抑制细胞外钙流入收缩成分的物质，通常会消除增强作用。在其他目前未明确的增强作用中，应将对钙利用的影响视为一种可能的机制。
Evidence was obtained for a previously unidentified form of sensitization in vascular smooth muscle related to calcium utilization. The quaternary ammonium compound tetraethylammonium potentiated the amplitude of contractions elicited by a variety of agonists in rabbit aortic strips. The potentiating effect was not reduced in strips from rabbits pretreated with reserpine to deplete endogenous catecholamine. An analysis of the mechanism of enhancement indicated that tetraethylammonium increased the utilization of extracellular and/or loosely bound calcium for contraction. It was found that potentiation was much reduced and usually blocked in a low-calcium solution. In addition, SKF-525A, a substance that inhibits selectively the influx of extracellular calcium to the contractile elements, generally abolished enhancement. Effects on calcium utilization should be considered as a possible mechanism in other currently undefined potentiations.