Paravascular fluid dynamics reveal arterial stiffness assessed using dynamic diffusion-weighted imaging.
Paravascular fluid dynamics reveal arterial stiffness assessed using dynamic diffusion-weighted imaging.
复制标题
血管旁流体动力学揭示了使用动态扩散加权成像评估的动脉僵硬度。
DOI：
10.1002/nbm.5048
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发表时间：
2024
影响因子：
2.9
通讯作者：
Riley,Kalen
中科院分区：
文献类型：
--
作者：
Wen,Qiuting;Wright,Adam;Tong,Yunjie;Zhao,Yi;Risacher,ShannonL;Saykin,AndrewJ;Wu,Yu-Chien;Limaye,Kaustubh;Riley,Kalen
淋巴系统内脑动脉周围的脑血管旁脑脊液(PCSF)是搏动性的，与血管壁的压力波同步运动。这种搏动性的pCSF是否可以推断脉搏波的传播--一种与动脉僵硬密切相关的特性--是未知的，也从未被探索过。我们最近开发的动态扩散加权成像(DynDWI)技术可以捕捉到活体pCSF的脉动动力学，并可以探索这一问题。在这项工作中，我们评估了pCSF波和手指脉搏波之间的时移，其中pCSF波是通过dynDWI测量的，手指脉搏波是通过扫描仪内置的手指脉搏血氧仪测量的。我们假设时移反映了脑指脉搏波的传播时间，并且对动脉僵硬很敏感。我们将该框架应用于36名年龄在18-82岁( )的参与者，以研究旅行时间的年龄效应，以及它与老年参与者(N =15，年龄&60岁)认知功能的关系。我们的结果显示pCSF脉搏和指脉之间有很强且一致的相关性(平均CorCoff = 为0.66)，支持动脉搏动是pCSF动态变化的主要驱动因素。脉搏与指脉之间的时间延迟(TimeDelay)随年龄增长而显著降低(即脉冲传播速度更快)(Pearson‘sr= −0.44，p= 0.007)。在年龄较大的参与者中，延迟时间较短进一步与认知功能较差有关。总体而言，我们的研究表明pCSF是一种测量颅内脉搏的可行途径，并鼓励未来的研究探讨其与脑血管功能的相关性。
Paravascular cerebrospinal fluid (pCSF) surrounding the cerebral arteries within the glymphatic system is pulsatile and moves in synchrony with the pressure waves of the vessel wall. Whether such pulsatile pCSF can infer pulse wave propagation—a property tightly related to arterial stiffness—is unknown and has never been explored. Our recently developed imaging technique, dynamic diffusion‐weighted imaging (dynDWI), captures the pulsatile pCSF dynamics in vivo and can explore this question. In this work, we evaluated the time shifts between pCSF waves and finger pulse waves, where pCSF waves were measured by dynDWI and finger pulse waves were measured by the scanner's built‐in finger pulse oximeter. We hypothesized that the time shifts reflect brain‐finger pulse wave travel time and are sensitive to arterial stiffness. We applied the framework to 36 participants aged 18–82 years to study the age effect of travel time, as well as its associations with cognitive function within the older participants (N =15, age > 60 years). Our results revealed a strong and consistent correlation between pCSF pulse and finger pulse (mean CorrCoeff = 0.66), supporting arterial pulsation as a major driver for pCSF dynamics. The time delay between pCSF and finger pulses (TimeDelay) was significantly lower (i.e., faster pulse propagation) with advanced age (Pearson'sr= −0.44,p= 0.007). Shorter TimeDelay was further associated with worse cognitive function in the older participants. Overall, our study demonstrated pCSF as a viable pathway for measuring intracranial pulses and encouraged future studies to investigate its relevance with cerebrovascular functions.