Initial human experience of endoscopic ultrasound-guided photodynamic therapy with a novel photosensitizer and a flexible laser-light catheter
Initial human experience of endoscopic ultrasound-guided photodynamic therapy with a novel photosensitizer and a flexible laser-light catheter
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DOI：
10.1055/s-0034-1392150
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发表时间：
2015-11-01
期刊：
影响因子：
9.3
通讯作者：
Park, Do Hyun
中科院分区：
文献类型：
--
作者：
Choi, Jun-Ho;Oh, Dongwook;Park, Do Hyun
背景和研究目的：内镜下选择性消融局部晚期胰胆管恶性肿瘤的新方法是一种微创方法。我们的目的是研究超声内镜（EUS）引导下的光动力治疗（PDT）对局部晚期胰胆管恶性肿瘤患者局部肿瘤控制的可行性和安全性。患者和方法：采用氯e6衍生物和柔性激光导管对4例局部晚期胰胆管恶性肿瘤患者进行eus引导的PDT治疗。结果：eus引导下的PDT在所有4例局部晚期胰胆管恶性肿瘤患者（2例在肝尾状叶，1例在远端胆管，1例在胰腺尾部）中技术上是可行的。无治疗相关并发症发生。PDT造成的坏死中位体积为4.0cm(3)（范围0.7-11.3）。在中位随访5个月（范围3-7个月）期间，所有4例患者的病情保持稳定。结论：这些初步数据表明，第二代光敏剂和柔性激光探针的eus引导PDT是可行和安全的。
Background and study aims: New methods for the endoscopic selective ablation of locally advanced pancreaticobiliary malignancies as a minimally invasive approach are needed. Our aim was to examine the feasibility and safety of endoscopic ultrasonography (EUS)-guided photodynamic therapy (PDT) for local tumor control in patients with locally advanced pancreaticobiliary malignancies.Patients and methods: A chlorin e6 derivative and a flexible laser-light catheter were used to perform EUS-guided PDT in four patients with locally advanced pancreaticobiliary malignancies.Results: EUS-guided PDT was technically feasible in all four patients with locally advanced pancreaticobiliary malignancies (two in the caudate lobe of the liver, one in the far distal bile duct, and one in the tail of the pancreas). No treatment-related complications occurred. The median volume of necrosis produced by PDT was 4.0cm(3) (range 0.7-11.3). Disease remained stable in all four patients during a median follow-up of 5 months (range 3-7).Conclusion: These preliminary data suggest that EUS-guided PDT with a second-generation photosensitizer and a flexible laser probe is feasible and safe.