Synthesis of pH stable, blue light-emitting diode-excited, fluorescent silica nanoparticles and effects on cell behavior.
Synthesis of pH stable, blue light-emitting diode-excited, fluorescent silica nanoparticles and effects on cell behavior.
复制标题
DOI：
10.2147/ijn.s139562
复制
发表时间：
2017
影响因子：
8
通讯作者：
Beck GR Jr
中科院分区：
文献类型：
--
作者：
Ha SW;Lee JK;Beck GR Jr
迄今为止，将发光二极管（LED）激活的化合物输送到细胞和组织仍然是一个挑战。硅基材料具有良好的生物相容性和尺寸、形状控制的优点。荧光二氧化硅纳米颗粒（NPs）已被合成并用于细胞跟踪和肿瘤识别等应用。在这里，我们报道了荧光二氧化硅NPs的合成和优化，该NPs将萘酰亚胺染料与三乙氧基硅烷结合，由蓝色LED波长激发（LEDex NPs）。NPs可以在420-470 nm波长成像，显示出高量子产率，在pH范围内稳定，并且可以进入细胞。因此，这些NPs代表了一种新的生物医学成像技术。
To date, delivery of light-emitting diode (LED)-activated compounds to cells and tissue remains a challenge. Silica-based materials possess good biocompatibility and have advantages of control of size and shape. Fluorescent silica nanoparticles (NPs) have been synthesized and used for applications such as cell tracking and tumor identification. Here, we report the synthesis and optimization of fluorescent silica NPs, which incorporate a naphthalimide dye with triethoxysilanes that are excited by the blue LED wavelength (LEDex NPs). The NPs can be imaged in the 420–470 nm wavelength, demonstrate a high quantum yield, are stable in a range of pH, and are taken into the cells. Therefore, these NPs represent a novel imaging technology for biomedical applications.