Association between inflammatory bowel disease and bullous pemphigoid: a population-based case-control study
Association between inflammatory bowel disease and bullous pemphigoid: a population-based case-control study
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DOI：
10.1038/s41598-020-69475-0
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发表时间：
2020-07-29
影响因子：
4.6
通讯作者：
Tseng, Hsiao-Ching
中科院分区：
文献类型：
--
作者：
Chen, Yi-Ju;Juan, Chao-Kuei;Tseng, Hsiao-Ching
炎症性肠病（IBD）和大疱性类天疱疮（BP）并存已有报道。迄今为止，还没有大规模的研究探讨这些疾病之间的关系。这项基于人群的病例对照研究通过使用全国范围的数据库来检查IBD和BP之间的关联。在台湾国民健康保险研究数据库（1997-2013）中，共确定了5，263名BP患者和21，052名年龄和性别，医院访视次数匹配的对照。比较人口统计学特征和合并症（包括IBD）。采用Logistic回归分析BP的预测因素。诊断时的平均年龄为74.88岁，54.3%的受试者为男性。BP患者往往有更多的心血管危险因素，自身免疫和神经系统共病，血液系统癌症比匹配的对照。BP患者中有20例IBD（0.38%），主要是溃疡性结肠炎（N=17，0.32%），而对照组中有33例IBD（0.16%）（p
The coexistence of inflammatory bowel disease (IBD) and bullous pemphigoid (BP) has been reported. No large-scale study to date has explored the relationship between these diseases. This population-based case-control study examined the association between IBD and BP by using a nationwide database. A total of 5,263 BP patients and 21,052 age- and gender-, hospital visit number-matched controls were identified in the National Health Insurance Research Database of Taiwan (1997-2013). Demographic characteristics and comorbidities including IBD were compared. Logistic regression was conducted to examine the predicting factors for BP. The mean age at diagnosis was 74.88 years and 54.3% of subjects were male. BP patients tended to have more cardiovascular risk factors, autoimmune and neurologic comorbidities, and hematologic cancers than matched controls. There were 20 cases of IBD (0.38%), mostly ulcerative colitis (N=17, 0.32%) among BP patients, compared to 33 IBD cases (0.16%) among controls (p