BIRTH OF PROJECTION NEURONS IN THE HIGHER VOCAL CENTER OF THE CANARY FOREBRAIN BEFORE, DURING, AND AFTER SONG LEARNING
BIRTH OF PROJECTION NEURONS IN THE HIGHER VOCAL CENTER OF THE CANARY FOREBRAIN BEFORE, DURING, AND AFTER SONG LEARNING
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DOI：
10.1073/pnas.85.22.8722
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发表时间：
1988-11-01
影响因子：
11.1
通讯作者：
NOTTEBOHM, F
中科院分区：
文献类型：
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作者：
ALVAREZBUYLLA, A;THEELEN, M;NOTTEBOHM, F
金丝雀脑的高级发声中心 (HVc) 投射到两个前脑核：古纹状体粗壮肌 (RA) 和增殖叶 X 区。通过结合[3P]胸苷放射自显影和逆行荧光金摄取来确定投射到这两个区域的 HVc 神经元的诞生时间。在 X 区或 RA 区注射荧光金后 4 天，13 个月大时处死家禽。在卵内（胚胎第 9 天）单次注射 [3H]胸苷标记了 76% 的 X 投影区域细胞和 0.8% 的 RA 区域细胞。绝大多数 RA 投射细胞是在孵化后发育期间产生的（孵化后第 10-240 天；P10-P240），在 P60 处达到峰值，在 P120 处中断。 HVc 在 P240 时达到完全成年尺寸，但在该年龄，新 RA 投射细胞的产生继续以与孵化后发育期间记录的速度相当（孵化后第 10-240 天；P10-P240），在 P60 达到峰值，在 P120 出现中断。 HVc 在 P240 时达到完全成年尺寸，但在该年龄，新的 RA 投射细胞的产生继续以与孵化后发育期间记录的速度相当的速度进行。连接大脑两个遥远区域的神经元的晚期产生可能会调节源细胞群到目标细胞群的大小。雄性金丝雀在 P40 开始唱歌。在接下来的几个月里，他们模仿外部模特，他们的歌曲变得更加结构化和刻板。性成熟时（P240），歌曲稳定。提供了三种解释：(i) RA 投射细胞的神经发生与学习有关，即使在实现模式稳定性后学习仍在继续； (ii) RA 投射细胞的神经发生与学习无关 (iii) RA 投射细胞的产生在发育期间和性成熟后有不同的目的。
The higher vocal center (HVc) of the canary brain projects to two forebrain nuclei: robustus archistriatalis (RA) and area X of lobus proliferatorius. The time of birth of HVc neurons projecting to these two regions was determined by combining [3P]thymidine autoradiography and retrograde fluorogold uptake. Birds were sacrificed at 13 months of age, 4 days after fluorogold injections into area X or RA. A single injection of [3H]thymidine in ovo (embryonic day 9) labeled 76% of area X-projecting cells and 0.8% of cells projecting to RA. The great majority of RA-projecting cells were produced during posthatching development (posthatching day 10-240; P10-P240), with a peak at P60 and a hiatus at P120. HVc reaches full adult size by P240, yet at that age the production of new RA-projecting cells continued at a rate comparable to that recorded during posthatching development (posthatching day 10-240; P10-P240), with a peak at P60 and a hiatus at P120. HVc reaches full adult size by P240, yet at that age the production of new RA-projecting cells continued at a rate comparable to that recorded during posthatching development. Late production of neurons interconnecting two distant regions of the brain may regulate source to target cell population size. Male canaries start to sing at P40. During subsequent months, they imitate external models and their song becomes more structured and stereotyped. At sexual maturity (P240), song is stable. Three interpretations are offered: (i) neurogenesis of RA-projecting cells is related to learning, and learning continues even after achievement of pattern stability; (ii) neurogenesis of RA-projecting cells is not related to learning (iii) the production of RA-projecting cells serves different purposes during development and after sexual maturity.