Strategies for the Biofunctionalization of Gold and Iron Oxide Nanoparticles
Strategies for the Biofunctionalization of Gold and Iron Oxide Nanoparticles
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DOI：
10.1021/la5015658
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发表时间：
2014-12-23
期刊：
影响因子：
3.9
通讯作者：
de la Fuente, Jesus M.
中科院分区：
文献类型：
--
作者：
Fratila, Raluca M.;Mitchell, Scott G.;de la Fuente, Jesus M.
纳米技术应用于医学（纳米医学）领域正在快速发展，有望为早期诊断、靶向治疗和个性化医疗提供解决方案。然而，设计用于生物医学应用的纳米材料并不是一项微不足道的任务。避免免疫系统，在生理介质中的稳定性，控制纳米材料与生物实体（如蛋白质和细胞膜）的相互作用，低毒性和最佳的生物相容性对于所设计的纳米材料的成功至关重要。在这篇专题文章中，我们简要概述了有关金和氧化铁纳米颗粒生物应用衍生化的一些最新进展。与金和氧化铁纳米粒子与碳水化合物，肽，核酸和抗体的功能化有关的最重要的方面都包括在内，突出了我们研究小组最近的贡献。我们建议这些无机纳米粒子的适当（生物）功能化的提示，以保持附着的生物分子的生物活性，并确保其随后在生理介质中的稳定性。
The field of nanotechnology applied to medicine (nanomedicine) is developing at a fast pace and is expected to provide solutions for early diagnosis, targeted therapy, and personalized medicine. However, designing nanomaterials for biomedical applications is not a trivial task. Avoidance of the immune system, stability in physiological media, control over the interaction of a nanomaterial with biological entities such as proteins and cell membranes, low toxicity, and optimal bioperformance are critical for the success of the designed nanomaterial. In this Feature Article we provide a concise overview of some of the most recent advances concerning the derivatization of gold and iron oxide nanoparticles for bioapplications. The most important aspects relating to the functionalization of gold and iron oxide nanoparticles with carbohydrates, peptides, nucleic acids, and antibodies are covered, highlighting the recent contributions from our research group. We suggest tips for the appropriate (bio)functionalization of these inorganic nanoparticles in order to preserve the biological activity of the attached biomolecules and ensure their subsequent stability in physiological media.