Entanglement-Driven Adhesion, Self-Healing, and High Stretchability of Double-Network PEG-Based Hydrogels
Entanglement-Driven Adhesion, Self-Healing, and High Stretchability of Double-Network PEG-Based Hydrogels
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双网络 PEG 水凝胶的缠结驱动粘附、自修复和高拉伸性
DOI：
10.1021/acsami.9b14348
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发表时间：
2019-10-09
影响因子：
9.5
通讯作者：
Wang, Huanan
中科院分区：
文献类型：
--
作者：
Chen, Kaiwen;Fen, Yangyingfan;Wang, Huanan
能够湿粘附和自愈合的水凝胶可以在各种生物医学应用中实现重大进展，例如组织再生、伤口敷料、可穿戴/可植入装置和药物递送。因此，我们开发了一种创新但简单的策略，以实现粘合剂，自愈合和高度可拉伸的双网络水凝胶，其由主要共价聚乙二醇二丙烯酸酯（PEGDA）网络与高度扩散的非共价网络的组合组成，巨大的PEG链。由于扩散性PEG链可以自发渗透并与基材网络缠结，因此与基材（包括组织基质）的粘附是即时和可重复的。结合PEG固有的生物相容性和用于调整水凝胶网络性质的合理设计，我们示例性地证明了这种氢可以用作细胞培养的三维基质或用作伤口愈合的组织粘合剂。体内研究表明，与目前临床使用的商业组织粘合剂相比，水凝胶能够有效地引发皮肤伤口愈合，免疫反应显著降低。因此，我们的研究提供了新的和关键的见解，设计策略，以实现粘附和rehealability的优势，从双网络水凝胶的缠结效应，并开辟了一个新的途径，缠结驱动的水凝胶在再生医学中的应用。
Hydrogels that are capable of wet adhesion and self-healing can enable major advances in a variety of biomedical applications such as tissue regeneration, wound dressings, wearable/implantable devices, and drug delivery. We hereby developed an innovative but simple strategy to achieve adhesive, self-healing, and highly stretchable double-network hydrogels, which were composed of a primary covalent polyethylene glycol diacrylate (PEGDA) network in combination with a noncovalent network of highly diffusive, giant PEG chains. The adhesion to substrates including tissue matrices was instant and repeatable due to the diffusive PEG chains that can spontaneously penetrate and entangle with the substrate network. Combining the intrinsic biocompatibility of PEG and rational design for tuning the hydrogel network properties, we exemplarily demonstrated that this hydrogen can be used as a three-dimensional matrix for cell culture or as a tissue adhesive for wound healing. The in vivo study showed that the hydrogel is capable of effectively triggering skin wound healing with a significantly lower immune response in comparison to commercial tissue adhesives currently used in clinics. Therefore, our study provides new and critical insights into the design strategy to achieve adhesion and rehealability by taking advantages of the entanglement effect from double-network hydrogels and opens up a new avenue for the application of entanglement-driven hydrogels in regenerative medicine.