Treadmill Exercise Reduces Neuroinflammation, Glial Cell Activation and Improves Synaptic Transmission in the Prefrontal Cortex in 3 × Tg-AD Mice.
Treadmill Exercise Reduces Neuroinflammation, Glial Cell Activation and Improves Synaptic Transmission in the Prefrontal Cortex in 3 × Tg-AD Mice.
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跑步机运动可减轻3×Tg - AD小鼠前额叶皮质的神经炎症、胶质细胞活化，并改善其突触传递。
DOI：
10.3390/ijms232012655
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发表时间：
2022-10-21
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
--
作者：
Physical exercise improves memory and cognition in physiological aging and Alzheimer’s disease (AD), but the mechanisms remain poorly understood. Here, we test the hypothesis that Aβ oligomer accumulation, neuroinflammation, and glial cell activation may lead to disruption of synaptic transmission in the prefrontal cortex of 3 × Tg-AD Mice, resulting in impairment of learning and memory. On the other hand, treadmill exercise could prevent the pathogenesis and exert neuroprotective effects. Here, we used immunohistochemistry, western blotting, enzyme-linked immunosorbent assay, and slice electrophysiology to analyze the levels of GSK3β, Aβ oligomers (Aβ dimers and trimers), pro-inflammatory cytokines (IL-1β, IL-6, and TNFα), the phosphorylation of CRMP2 at Thr514, and synaptic currents in pyramidal neurons in the prefrontal cortex. We show that 12-week treadmill exercise beginning in three-month-old mice led to the inhibition of GSK3β kinase activity, decreases in the levels of Aβ oligomers, pro-inflammatory cytokines (IL-1β, IL-6, and TNFα), and the phosphorylation of CRMP2 at Thr514, reduction of microglial and astrocyte activation, and improvement of excitatory and inhibitory synaptic transmission of pyramidal neurons in the prefrontal cortex of 3 × Tg-AD Mice. Thus, treadmill exercise reduces neuroinflammation, glial cell activation and improves synaptic transmission in the prefrontal cortex in 3 × Tg-AD mice, possibly related to the inhibition of GSK3β kinase activity.
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DOI：
10.3803/enm.2013.28.4.297
发表时间：
2013-12
期刊：
Endocrinology and metabolism (Seoul, Korea)
影响因子：
--
作者：
Kim YM;Song I;Seo YH;Yoon G
通讯作者：
Yoon G
影响因子：
6.1
作者：
Hu S;Begum AN;Jones MR;Oh MS;Beech WK;Beech BH;Yang F;Chen P;Ubeda OJ;Kim PC;Davies P;Ma Q;Cole GM;Frautschy SA
通讯作者：
Frautschy SA
影响因子：
7.8
作者：
Belfiore, Ramona;Rodin, Alexis;Oddo, Salvatore
通讯作者：
Oddo, Salvatore
DOI：
10.1073/pnas.220413597
发表时间：
2000-10-24
影响因子：
11.1
作者：
Fang, XJ;Yu, SX;Mills, GB
通讯作者：
Mills, GB
影响因子：
7.1
作者：
Ikezu, Seiko;Ingraham Dixie, Kaitlin L.;Ikezu, Tsuneya
通讯作者：
Ikezu, Tsuneya