Current and next generation influenza vaccines: Formulation and production strategies
Current and next generation influenza vaccines: Formulation and production strategies
复制标题
DOI：
10.1016/j.ejpb.2015.05.023
复制
发表时间：
2015-08-01
影响因子：
4.9
通讯作者：
Kersten, Gideon F. A.
中科院分区：
文献类型：
--
作者：
Soema, Peter C.;Kompier, Ronald;Kersten, Gideon F. A.
接种疫苗是预防流感感染的最有效方法。然而，目前的流感疫苗有几个局限性。生产时间相对较长、疫苗能力有限、对某些人群的效力中等以及缺乏交叉反应性是需要解决的重要问题。我们从跨学科的角度概述了流感疫苗的现状和新进展。新疫苗概念的可行性不仅取决于免疫学或临床结果，还取决于生物技术方面，如配方和生产方法，这些往往被忽视。此外，下一代流感疫苗的解决，这有望带来交叉反应的流感疫苗。这些进展表明，流感疫苗领域的前景令人兴奋。(C)2015作者由爱思唯尔公司出版
Vaccination is the most effective method to prevent influenza infection. However, current influenza vaccines have several limitations. Relatively long production times, limited vaccine capacity, moderate efficacy in certain populations and lack of cross-reactivity are important issues that need to be addressed. We give an overview of the current status and novel developments in the landscape of influenza vaccines from an interdisciplinary point of view. The feasibility of novel vaccine concepts not only depends on immunological or clinical outcomes, but also depends on biotechnological aspects, such as formulation and production methods, which are frequently overlooked. Furthermore, the next generation of influenza vaccines is addressed, which hopefully will bring cross-reactive influenza vaccines. These developments indicate that an exciting future lies ahead in the influenza vaccine field. (C) 2015 The Authors. Published by Elsevier B.V.