TISSUE BLOOD-GROUP ANTIGENS AND PROGNOSIS IN LOW STAGE TRANSITIONAL CELL-CARCINOMA OF BLADDER
TISSUE BLOOD-GROUP ANTIGENS AND PROGNOSIS IN LOW STAGE TRANSITIONAL CELL-CARCINOMA OF BLADDER
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DOI：
10.1016/s0022-5347(17)57379-6
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发表时间：
1978-01-01
影响因子：
6.6
通讯作者：
FRALEY, EE
中科院分区：
文献类型：
--
作者：
LANGE, PH;LIMAS, C;FRALEY, EE
肿瘤上皮细胞表面A、B或H血型抗原的丢失与侵袭性肿瘤行为相关。这种现象在膀胱移行细胞癌的低阶段进行了检查。在对37例患者的活检材料的分析中，原始或复发肿瘤上这些抗原的缺失与随后的侵袭性疾病（B期或更高）的发展相关，而抗原的存在与侵袭性疾病的发展失败相关。分析膀胱移行细胞表面抗原有助于提高膀胱癌的治疗效果。
The loss of A, B or H blood-group antigens from the surface of neoplastic epithelial cells was correlated with aggressive tumor behavior. This phenomenon was examined in low stage transitional cell carcinoma of the bladder. In an analysis of biopsy material from 37 patients the absence of these antigens on the original or recurrent tumors correlated with the subsequent development of invasive disease (stage B or greater), while the presence of antigens correlated with failure to develop invasive disease. Analysis of transitional cell surface antigens may help improve the therapy of bladder cancer.