A neurokinin-1 receptor antagonist reduced hypersalivation and gastric contractility related to emesis in dogs
A neurokinin-1 receptor antagonist reduced hypersalivation and gastric contractility related to emesis in dogs
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DOI：
10.1152/ajpgi.1998.275.5.g1193
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发表时间：
1998-11-01
影响因子：
4.5
通讯作者：
Shiroshita, Y
中科院分区：
文献类型：
--
作者：
Furukawa, N;Fukuda, H;Shiroshita, Y
研究了速动激肽-神经激肽-1 （NK1）受体在腹部迷走神经刺激引起的有效干呕、多涎和呕吐相关胃反应中的作用。迷走神经刺激导致唾液分泌和副交感神经节后纤维活动逐渐增加，胃体和胃窦松弛，以及有效的干呕吐。然而，假性干呕时，唾液过多和神经活动增加受到抑制，心房收缩力增强。一种NK1受体拮抗剂GR-205171消除了心房收缩力和有效干呕的增强，但对主体和心房舒张没有影响。GR-205171能抑制分泌过多和神经活动增加，但不能完全消除。舌神经刺激的反射性唾液分泌不受影响。这些结果表明，GR-205171作用于球茎的传入通路，减少与呕吐相关的唾液分泌过多和胃窦收缩以及有效的干呕，但不影响迷走神经、迷走唾液和舌唾液反射引起的胃松弛或唾液分泌过多。
The roles of tachykinin neurokinin-1 (NK1) receptors in the induction of fictive retching, hypersalivation, and gastric responses associated with emesis induced by abdominal vagal stimulation were studied in paralyzed, decerebrated dogs. Vagal stimulation induced gradual increases in salivary secretion and activity of the parasympathetic postganglionic fibers to the submandibular gland, relaxation of the gastric corpus and antrum, and fictive retching. However, hypersalivation and increased nerve activity were suppressed and antral contractility was enhanced during fictive retching. An NK1 receptor antagonist, GR-205171, abolished the enhancement of antral contractility and fictive retching but had no effect on corpus and antral relaxation. Hypersalivation and increased nerve activity were inhibited by GR-205171 but were not completely abolished. Reflex salivation by lingual nerve stimulation was unaffected. These results suggest that GR-205171 acts on the afferent pathway in the bulb and diminishes hypersalivation and antral contraction related to emesis as well as fictive retching but does not affect gastric relaxation or hypersalivation induced by the vagovagal, vagosalivary, and linguosalivary reflexes.