Drainage and antireflux characteristics of a biodegradable self-reinforced, self-expanding X-ray-positive ploy-L,D-lactide spiral partial Ureteral stent: An experimental study
Drainage and antireflux characteristics of a biodegradable self-reinforced, self-expanding X-ray-positive ploy-L,D-lactide spiral partial Ureteral stent: An experimental study
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DOI：
10.1089/end.2005.0085
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发表时间：
2007-12-01
影响因子：
2.7
通讯作者：
Tormala, Pertti
中科院分区：
文献类型：
--
作者：
Lumiaho, Juha;Heino, Antero;Tormala, Pertti
目的：评价一种新型自膨胀自增强聚l， d -丙交酯部分输尿管支架（sr - pl96）在实验模型中的引流和抗反流特性。材料与方法：以12只犬为实验动物。所有动物均行低中线剖腹和膀胱切开术。A组（6只）将50 mm长的SR-PLA 96型输尿管支架置入输尿管两端，双螺旋设计，下端距输尿管膀胱连接处2 cm。B组（6只）输尿管均采用传统的尾纤支架(C-Flex (R) Double-J；Cook Urological)，手术后8周取出。术后6周和12周分别通过动态肾显像和尿路造影检查评估肾功能和输尿管通畅程度。6周时通过核排空膀胱造影评估输尿管两个水平和肾盂水平的膀胱输尿管反流程度。结果：部分SR-PLA 96支架设计比双j支架设计具有更好的抗反流性能。膀胱输尿管的回流的程度,反映在增加核增强6周,远较低(7.9% + / - 14.7% v 63.2% + / - 17.3%; P < 0.05)和中等(6.1% + / - 8.1%与45.5% + / - 19.5%;P = 0.15)水平的输尿管以及肾盂的水平(v + / - 3.6% 6.2% 3.9% 19.5% -3.4%; P = 0.15)水平的输尿管以及肾盂的水平(-3.4% v + / - 3.6% 6.2% + / - 3.9%, P = 0.65)比Double-J-stented输尿管。双j支架取出后12周，sr - pl96支架碎裂，两组患者肾功能及输尿管通畅无明显差异。结论：自膨胀、自增强的SR-PLA 96部分输尿管支架比Double-J支架具有更好的抗反流性能。
Purpose: To evaluate the drainage and antireflux characteristics of a new self-expandable self-reinforced poly-L,D-lactide partial ureteral stent (SR-PLA 96) in an experimental model.Materials and Methods: Twelve dogs were used as experimental animals. A low-midline laparotomy and cystotomy were performed on all animals. In group A (six animals), 50-mm long SR-PLA 96 ureteral stents with a double-helical spiral design were inserted into both ureters, leaving the lower ends 2 cm above the ureterovesical junction. In group B (six animals), both ureters were stented with traditional pigtail stents (C-Flex (R) Double-J; Cook Urological), which were removed 8 weeks after surgery. Renal function and ureteral patency were evaluated by dynamic kidney imaging and urography examinations at 6 and 12 weeks postoperatively. The degrees of vesicoureteral reflux at two levels of the ureters and at the level of the renal pelvis were evaluated by nuclear voiding cystograms at 6 weeks.Results: The partial SR-PLA 96 stent design showed more favorable antireflux properties that the Double-J stent design. The degree of vesicoureteral reflux, reflected in an increase of nuclear enhancement at 6 weeks, was lower in the distal (7.9 % +/- 14.7 % v 63.2 % +/- 17.3 %; P < 0.05) and middle (6.1 % +/- 8.1 % v. 45.5 % +/- 19.5%; P = 0.15) levels of the ureters as well as at the level of the renal pelvis (-3.4% +/- 3.6% v 6.2% 3.9% 19.5%; P = 0.15) levels of the ureters as well as at the level of the renal pelvis (-3.4% +/- 3.6% v 6.2% +/- 3.9% P = 0.65) than in the Double-J-stented ureters. No significant differences in renal function or ureteral patency were observed at 12 weeks after the Double-J stents had been removed and the SR-PLA 96 stents had fragmented.Conclusion: A self-expandable, self-reinforced SR-PLA 96 partial ureteral stent showed more favorable antireflux properties than a Double-J stent.