Astragaloside IV attenuates cerebral ischemia-reperfusion-induced increase in permeability of the blood-brain barrier in rats
Astragaloside IV attenuates cerebral ischemia-reperfusion-induced increase in permeability of the blood-brain barrier in rats
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DOI：
10.1016/j.ejphar.2009.01.022
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发表时间：
2009-03-15
影响因子：
5
通讯作者：
Gao, Guo Dong
中科院分区：
文献类型：
--
作者：
Qu, You Zhi;Li, Min;Gao, Guo Dong
黄芪在中国医案中广泛用于治疗中风和慢性衰弱疾病，但其作用机制尚未得到充分的资料论证。本研究采用大鼠局灶性脑缺血再灌流模型，观察黄芪皂苷IV对大鼠局灶性脑缺血再灌注损伤后血脑屏障通透性的影响。伊文思蓝渗漏法检测发现，黄芪甲苷(10、20 mg/kg)能显著降低缺血再灌注后血脑屏障的通透性(P
Astragalus membranaceus is widely used to treat stroke and chronic debilitating diseases in China, but the mechanism has not been fully demonstrated to data. In the present study, we, using astragaloside IV, a purified extract from astragalus membranaceus, to a focal cerebral ischemia/reperfusion rat model, aimed to investigate the effect of astragaloside IV on the permeability of the blood-brain barrier since disruption Of blood-brain harrier induced by ischemia/reperfusion leads to serious brain injuries. We found that astragaloside IV (10, 20 mg/kg) significantly attenuated the permeability of blood-brain barrier in comparison with vehicle group after ischemia/reperfusion assessed via Evans blue leakage (P