The value of repeat kidney biopsy in quiescent Argentinian lupus nephritis patients
The value of repeat kidney biopsy in quiescent Argentinian lupus nephritis patients
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DOI：
10.1177/0961203313518625
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发表时间：
2014-07-01
期刊：
影响因子：
2.6
通讯作者：
Rovin, B. H.
中科院分区：
文献类型：
--
作者：
Alvarado, A. S.;Malvar, A.;Rovin, B. H.
背景：狼疮性肾炎诱导治疗后维持治疗的持续时间尚未严格确定。通常的做法是在完全缓解后维持免疫抑制1 - 2年，部分缓解则维持更长时间。目前的工作地址是否重复肾活检可能是在决定谁应该继续免疫抑制后完全或部分缓解信息。研究方法：布宜诺斯艾利斯一家大型肾脏病单位的做法是，在最终决定是否停止或继续免疫抑制之前，重复进行肾活检。这项工作报告了一组25名西班牙裔患者，有两个或更多的肾活检，最后一次发生后，至少24个月的临床静止疾病。结果：尽管血清肌酐正常化和蛋白尿减少，
Background: The duration of maintenance therapy after induction therapy for lupus nephritis has not been rigorously established. A common practice is to maintain immunosuppression for 1-2 years after complete remission, and longer for partial remission. The present work addresses whether a repeat kidney biopsy might be informative in deciding who should continue immunosuppression after complete or partial remission. Methods: The practice in a large Buenos Aires nephrology unit is to repeat a kidney biopsy before finalizing the decision to withdraw or continue immunosuppression. This work reports on a cohort of 25 Hispanic patients that had two or more kidney biopsies, the last occurring after at least 24 months of clinically quiescent disease. Results: Despite normalization of serum creatinine and reduction of proteinuria to