CORONARY RISK ASSOCIATED WITH AGE AND SEX OF PARENTAL HEART-DISEASE IN THE FRAMINGHAM-STUDY
CORONARY RISK ASSOCIATED WITH AGE AND SEX OF PARENTAL HEART-DISEASE IN THE FRAMINGHAM-STUDY
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DOI：
10.1016/0002-9149(89)90477-3
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发表时间：
1989-09-15
影响因子：
2.8
通讯作者：
KANNEL, WB
中科院分区：
文献类型：
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作者：
SCHILDKRAUT, JM;MYERS, RH;KANNEL, WB
Framingham 研究是一项针对 5,209 人的基于人群的前瞻性研究，分析了其数据，以确定 65 岁之前或之后父母因冠状动脉疾病 (CAD) 死亡史是否是队列中男性和女性早发（年龄小于 60 岁）或晚发（60 岁或以上）CAD 的独立危险因素。父母因 CAD 死亡与 CAD 风险增加 30% 相关。对于早期 CAD 结局，这种效应明显更强，调整后的早期 CAD 相对风险为 1.5，晚期结局 CAD 为 1.2。父母 CAD 死亡对风险的影响不受其他 CAD 共同风险因素的调节。如果后代的 CAD 发病发生在 60 岁之前，那么对于母亲或父亲患有 CAD 的人来说，这些发现是相似的。对于 60 岁或以上患有 CAD 的人来说，母亲 CAD 死亡比父亲 CAD 死亡更能预测 CAD。该队列中的男性和女性与父母 CAD 病史的相关性相似，调整后的相对风险分别为 1.3 和 1.2。然而，父母 CAD 死亡年龄较早可能是女性之间相关性的原因 (RR = 1.6)，而父母任何一方 CAD 死亡年龄较晚与男性患 CAD 风险相关 (RR = 1.4)。
Data from the Framingham Study, a population-based prospective study of 5,209 persons, were analyzed to determine whether a parental history of death by coronary artery disease (CAD) before or after 65 years of age was an independent risk factor for CAD of early onset (age younger than 60 years) or late onset (age 60 years or older) among the men and women in the cohort. Death due to CAD in parents was associated with a 30% increase in the risk of CAD. The effect was apparently stronger for an early CAD outcome, with adjusted relative risks of 1.5 for early and 1.2 for late outcome CAD. The effect of parental CAD death on risk was not mediated by other shared risk factors for CAD. These findings were similar for those with either a mother or a father with CAD, if CAD onset in the offspring occurred before the age of 60 years. For persons with CAD at age 60 years or older, maternal CAD death was a stronger predictor of CAD than paternal CAD death. The association with parental history of CAD was similar among men and women in the cohort, with adjusted relative risks of 1.3 and 1.2, respectively. However, early age of parental CAD death may account for the association among women (RR = 1.6), whereas late age of CAD death for either parent was associated with the risk of CAD among men (RR = 1.4).