Prospect of divergent roles for the CUL3 system in vascular endothelial cell function and angiogenesis
Prospect of divergent roles for the CUL3 system in vascular endothelial cell function and angiogenesis
复制标题
DOI：
10.1093/jb/mvx051
复制
发表时间：
2017-10
期刊：
影响因子：
--
通讯作者：
Tomohisa Sakaue;M. Maekawa;H. Nakayama;S. Higashiyama
中科院分区：
文献类型：
--
作者：
Tomohisa Sakaue;M. Maekawa;H. Nakayama;S. Higashiyama
在不同的病理生理条件下(如发育、妊娠、炎症、伤口愈合、组织再生、肿瘤生长等)的组织重塑和再生。需要血管生成，这是对细胞外微环境刺激的动态协调反应。在血管生成和血管抑制反应中，血管内皮细胞在血管形成和消退中起着核心作用。血管抑制反应是由关键因子如血管内皮生长因子和DLL4引起的，已被阐明。然而，内皮细胞是如何处理这些相互矛盾的信号的，目前还没有揭示。对VEGFR-Notch交叉信号的研究提供了一些线索。我们在这里讨论了基于cullin 3的泛素E3连接酶在内皮细胞功能和血管生成的各种信号过程中的潜在作用。我们最近的发现表明，它们作为一个单位来处理相互冲突的信号串扰、关键因素的表观遗传调节和功能障碍的维持。我们还期待基于cullin 3的泛素E3连接酶在内皮细胞功能和血管生成中发挥更多不同的作用，并将其作为潜在的治疗靶点。
Tissue remodelling and regeneration in various pathophysiological conditions (e.g. the processes of development, pregnancy, inflammation, wound healing, tissue regeneration, tumor growth, etc.) require angiogenesis, a dynamically coordinated response to stimuli from the extracellular microenvironment. During angiogenic and angiostatic responses, endothelial cells play a central role in the blood vessel formation and regression. Angiostatic responses, which are evoked by crucial factors such as VEGF and DLL4, have been elucidated. However, it has not been revealed, how endothelial cells process these conflicting signals. The study of VEGFR-Notch cross-signalling provided some clues. We discuss here the potential roles of cullin 3-based ubiquitin E3 ligases as key players in the process of various signals in endothelial cell function and angiogenesis. Our recent findings show that they function as units to process conflicting signalling crosstalk, epigenetic regulation of key factors, and functional barrier maintenance. We also expect more divergent roles of cullin 3-based ubiquitin E3 ligases in endothelial cell function and angiogenesis, and for their potential use as therapeutic targets.