Cortical activation and language task difficulty in aphasia
Cortical activation and language task difficulty in aphasia
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DOI：
10.1080/02687030444000714
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发表时间：
2005-03-01
期刊：
影响因子：
2
通讯作者：
Morrow, L
中科院分区：
文献类型：
--
作者：
Fridriksson, J;Morrow, L
背景：以前的研究使用功能性磁共振成像（fMRI）表明，皮质激活的变化作为任务难度增加的函数。这种关系还没有被探索的人与失语症，即使它可能有显着的影响，治疗前和治疗后的fMRI data.Aims的解释：这项探索性研究的目的是调查之间的关系，在语言任务的难度和皮层激活失语症的人。四名患有慢性失名症或布罗卡失语症的人和四名匹配的对照参与者在执行图片-单词匹配任务时进行了fMRI。与更困难的任务条件相比，所有参与者在更容易的条件下表现出更高的准确性。此外，更大的平均血氧水平依赖（BOLD）的信号强度和区域招聘期间注意到更困难的条件下，三个四个人失语症，以及三个四个控制。皮质活动的增加主要是注意到在上级颞叶和后下额叶lobes.Conclusions：目前的研究结果反映了在以前的研究中发现的正常受试者中，皮质激活增加并行任务难度为我们的大多数参与者。目前还不清楚是什么机制导致了这种效应;这种现象可能需要在未来的失语症治疗相关的神经可塑性的功能磁共振成像研究中考虑。
Background: Previous research using functional MRI (fMRI) suggests changes in cortical activation as a function of increased task difficulty. This relationship has not been explored in persons with aphasia even though it may have significant implications for pre- and posttreatment interpretation of fMRI data.Aims: The purpose of this exploratory study was to investigate the relationship between changes in language task difficulty and cortical activation in persons with aphasia.Methods & Procedures: Four persons with chronic anomic or Broca's aphasia and four matched control participants underwent fMRI while performing a picture-word matching task.Outcomes & Results: Compared to the more difficult task condition, all participants performed with greater accuracy on the easier condition. Moreover, greater mean blood oxygenated level dependent (BOLD) signal intensity and area recruitment were noted during the more difficult condition for three out of four persons with aphasia as well as three of the four controls. The increase in cortical activity was mainly noted in the superior temporal and posterior inferior frontal lobes.Conclusions: The present findings mirror those found in previous studies of normal subjects in that cortical activation increased in parallel to task difficulty for most of our participants. It is unclear what mechanism accounts for this effect; this phenomenon might need to be considered in future fMRI studies of neural plasticity associated with aphasia treatment.