Effect of inherent urine output on the response of male rats to 7.5% dietary sodium saccharin.
Effect of inherent urine output on the response of male rats to 7.5% dietary sodium saccharin.
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效果％20的％20固有的％20尿液％20输出％20对％20的％20反应％20的％20雄性％20大鼠％20到％207.5％％20饮食％20钠％20糖精。
DOI：
10.1016/0278-6915(87)90097-4
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
J. Maurer
中科院分区：
文献类型：
--
作者：
R. Anderson;F. Lefever;J. Maurer
将年轻雄性大鼠预选为高尿组（57 g/kg体重）或低尿组（35 g/kg体重），饲喂含7.5%糖精钠（NaS）的饲粮10周。研究发现，排尿量是一个稳定的特征，高排尿量与水和饲料消耗增加以及体重增加有关。大鼠对7.5%的膳食NaS的反应非常相似，而不考虑其固有的尿量。NaS摄入与饮水量、盲肠质量和尿量增加有关。在摄入7.5%膳食NaS 10周的大鼠中，膀胱上皮增生的发生率很高（12 20）。结果讨论了关于增加尿量是一个重要因素的概念，在nas诱导膀胱肿瘤。
Young male rats were preselected as high urine (57 g/kg body weight) or low urine (35 g/kg) voiders and were fed a diet containing 7.5% sodium saccharin (NaS) for 10 wk. Urine output was found to be a stable characteristic and high urine output was associated with increased water and feed consumption and increased weight gain. Rats responded in a very similar fashion to 7.5% dietary NaS regardless of their inherent urine output. NaS ingestion was associated with increases in water consumption, caecal mass and urine volume. Among rats that had ingested 7.5% dietary NaS for 10 wk there was a high incidence (12 20) of bladder epithelial hyperplasia. The results are discussed with regard to the concept that increased urine output is an important factor in NaS-induced bladder tumours.