Renal Complications Following Lung Transplantation and Heart Transplantation
Renal Complications Following Lung Transplantation and Heart Transplantation
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DOI：
10.1016/j.ccc.2018.08.009
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发表时间：
2019-01-01
影响因子：
4.3
通讯作者：
Kellum, John A.
中科院分区：
文献类型：
--
作者：
Puttarajappa, Chethan M.;Bernardo, Jose F.;Kellum, John A.
肾脏并发症是心脏和/或肺移植后常见的并发症，并导致发病率和死亡率增加。肾功能不全也与移植等待名单上的患者的死亡率增加有关。在大多数中心，透析依赖是心脏或肺移植的相对禁忌症，此类患者通常被列为同时肾移植。有几个因素导致接受心脏和/或肺移植的患者肾功能受损，包括心肺和肾血流动力学之间的相互作用、复杂的围手术期问题和暴露于肾毒性药物（主要是钙调磷酸酶抑制剂）。
Renal complications are common following heart and/or lung transplantation and lead to increased morbidity and mortality. Renal dysfunction is also associated with increased mortality for patients on the transplant wait list. Dialysis dependence is a relative contraindication for heart or lung transplantation at most centers, and such patients are often listed for a simultaneous kidney transplant. Several factors contribute to the impaired renal function in patients undergoing heart and/or lung transplantation, including the interplay between cardiopulmonary and renal hemo-dynamics, complex perioperative issues, and exposure to nephrotoxic medications, mainly calcineurin inhibitors.