Jatrofolianes A and B: Two Highly Modified Lathyrane Diterpenoids from Jatropha gossypiifolia
Jatrofolianes A and B: Two Highly Modified Lathyrane Diterpenoids from Jatropha gossypiifolia
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Jatrofolianes A 和 B：来自麻风树的两种高度修饰的山楂二萜类化合物
DOI：
10.1021/acs.orglett.9b04029
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发表时间：
2019
期刊：
影响因子：
5.2
通讯作者：
Yin Sheng
中科院分区：
文献类型：
--
作者：
Li Wei;Tang Ya-Qi;Sang Jun;Fan Run-Zhu;Tang Gui-Hua;Yin Sheng
麻风树烷A（1）和B（2）是从棉叶麻风树（Jatropha gossypiifolia）中分离得到的两个高度修饰的lathyrane型二萜化合物，1含有一个不寻常的跨环1，3-二氧戊环结构，形成独特的5/6/5/8/3环体系，2具有一个新的10，11：1,3，14-diseco lathyrane骨架和一个12元大环内酯环。通过光谱分析、量子化学计算和单晶X-射线衍射确定了化合物的结构。化合物2在10 μM浓度下对肝癌细胞HepG 2/ADR和HCT-15/5-FU具有明显的多药耐药逆转活性。
Jatrofolianes A (1) and B (2), which are two highly modified lathyrane diterpenoids, were isolated fromJatropha gossypiifolia.1incorporates an unusual transannular 1,3-dioxolane moiety, forming a unique 5/6/5/8/3 ring system, while2possesses a new 10,11:13,14-diseco-lathyrane skeleton with a 12-membered macrocyclic lactone ring. Their structures were determined by spectroscopic analysis, quantum chemical calculations, and single-crystal X-ray diffraction.2showed significant multidrug resistance (MDR) reversal activity to cancer cells HepG2/ADR and HCT-15/5-FU at 10 μM.