Blueberry-enriched diet protects rat heart from ischemic damage.
Blueberry-enriched diet protects rat heart from ischemic damage.
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DOI：
10.1371/journal.pone.0005954
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发表时间：
2009-06-18
期刊：
影响因子：
3.7
通讯作者：
Talan M
中科院分区：
文献类型：
--
作者：
Ahmet I;Spangler E;Shukitt-Hale B;Juhaszova M;Sollott SJ;Joseph JA;Ingram DK;Talan M
评估蓝莓强化饮食(BD)的心脏保护特性。活性氧自由基(ROS)在缺血性心肌损伤中起重要作用。试图使用合成抗氧化剂来阻止ROS的有害影响，已经产生了混合或负面的结果，促使人们对天然产品的兴趣。蓝莓是水果和蔬菜中抗氧化能力最强的容易获得的产品。取青年雄性Fischer-344大鼠心肌细胞，分别给予补肾益气汤3个月或正常对照饲料(CD)，测定心肌细胞线粒体通透性转换阈值(TMPT)。与CD相比，BD导致ROS指数的TMPT增加了24%(p<；0.001)。其余的动物接受了冠状动脉左降支的永久性结扎。24小时后，BD大鼠的心肌梗死(MI)比CD大鼠减少22%(p<；0.01)。与CD大鼠相比，患BD的心肌区TUNEL(+)心肌细胞明显减少(2%比9%)，炎症细胞减少40%(p<；0.01)。在亚组大鼠冠状动脉结扎后，继续或改变原来的饮食，并进行心脏重塑和心肌梗死扩大，连续10周的超声心动图检查。测量表明，持续的BD或在MI后停止BD会减弱或加速MI后心脏重构和MI扩张的速度。富含蓝莓的饮食保护心肌免受诱导的缺血损伤，并显示出减缓心肌梗死后慢性心力衰竭的发展的潜力。
to assess the cardioprotective properties of a blueberry enriched diet (BD). Reactive oxygen species (ROS) play a major role in ischemia-related myocardial injury. The attempts to use synthetic antioxidants to block the detrimental effects of ROS have produced mixed or negative results precipitating the interest in natural products. Blueberries are readily available product with the highest antioxidant capacity among fruits and vegetables. Following 3-mo of BD or a regular control diet (CD), the threshold for mitochondrial permeability transition (tMPT) was measured in isolated cardiomyocytes obtained from young male Fischer-344 rats. Compared to CD, BD resulted in a 24% increase (p<0.001) of ROS indexed tMPT. The remaining animals were subjected to a permanent ligation of the left descending coronary artery. 24 hrs later resulting myocardial infarction (MI) in rats on BD was 22% less than in CD rats (p<0.01). Significantly less TUNEL(+) cardiomyocytes (2% vs 9%) and 40% less inflammation cells were observed in the myocardial area at risk of BD compared to CD rats (p<0.01). In the subgroup of rats, after coronary ligation the original diet was either continued or switched to the opposite one, and cardiac remodeling and MI expansion were followed by serial echocardiography for 10 weeks. Measurements suggested that continuation of BD or its withdrawal after MI attenuated or accelerated rates of post MI cardiac remodeling and MI expansion. A blueberry-enriched diet protected the myocardium from induced ischemic damage and demonstrated the potential to attenuate the development of post MI chronic heart failure.
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DOI：
10.1152/ajpheart.00711.2002
发表时间：
2003-02-01
影响因子：
4.8
作者：
Kevin, LG;Camara, AKS;Stowe, DF
通讯作者：
Stowe, DF
影响因子：
3.3
作者：
Das, Undurti N
通讯作者：
Das, Undurti N
影响因子：
37.8
作者：
Ahmet, I;Krawczyk, M;Talan, MI
通讯作者：
Talan, MI
影响因子：
4.1
作者：
Egger, T;Schuligoi, R;Sattler, W
通讯作者：
Sattler, W
DOI：
10.1016/s0022-2828(03)00230-x
发表时间：
2003-09-01
影响因子：
5
作者：
Li, SM;Li, X;Rozanski, GJ
通讯作者：
Rozanski, GJ