Rapid access to oxindoles by the combined use of an Ugi four-component reaction and a microwave-assisted intramolecular Buchwald-Hartwig amidation reaction
Rapid access to oxindoles by the combined use of an Ugi four-component reaction and a microwave-assisted intramolecular Buchwald-Hartwig amidation reaction
复制标题
DOI：
10.1021/ol061755z
复制
发表时间：
2006-09-14
期刊：
影响因子：
5.2
通讯作者：
Zhu, Jieping
中科院分区：
文献类型：
--
作者：
Bonnaterre, Florence;Bois-Choussy, Michele;Zhu, Jieping
一个两步序列，包括Ugi四组分反应（Ugi-4CR）和钯催化的分子内酰胺化芳基碘已被开发用于快速获得功能化的羟吲哚（1）。微波加热用于加速和提高分子内Buchwald-Hartwig反应的效率。
A two-step sequence involving an Ugi four-component reaction (Ugi-4CR) and a palladium-catalyzed intramolecular amidation of aryl iodide has been developed for rapid access to functionalized oxindole (1). Microwave heating was used to accelerate and to improve the efficiency of the intramolecular Buchwald-Hartwig reaction.