The Multifaceted Roles of KCC2 in Cortical Development
The Multifaceted Roles of KCC2 in Cortical Development
复制标题
DOI：
10.1016/j.tins.2021.01.004
复制
发表时间：
2021-02
影响因子：
15.9
通讯作者：
Mari A. Virtanen;P. Uvarov;Martina Mavrovic;J. Poncer;K. Kaila
中科院分区：
文献类型：
--
作者：
Mari A. Virtanen;P. Uvarov;Martina Mavrovic;J. Poncer;K. Kaila
KCC2, best known as the neuron-specific chloride-extruder that sets the strength and polarity of GABAergic currents during neuronal maturation, is a multifunctional molecule that can regulate cytoskeletal dynamics via its C-terminal domain (CTD). We describe the molecular and cellular mechanisms involved in the multiple functions of KCC2 and its splice variants, ranging from developmental apoptosis and the control of early network events to the formation and plasticity of cortical dendritic spines. The versatility of KCC2 actions at the cellular and subcellular levels is also evident in mature neurons during plasticity, disease, and aging. Thus, KCC2 has emerged as one of the most important molecules that shape the overall neuronal phenotype.
