From Lead Exposure in Early Childhood to Adolescent Health: A Chicago Birth Cohort
From Lead Exposure in Early Childhood to Adolescent Health: A Chicago Birth Cohort
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从幼儿期铅暴露到青少年健康：芝加哥出生队列
DOI：
10.2105/ajph.2017.303903
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发表时间：
2017
影响因子：
12.7
通讯作者：
R. Sampson
中科院分区：
文献类型：
--
作者：
Alix S. Winter;R. Sampson
目的评估儿童期铅暴露与青少年后期健康的3个方面（心理、身体和行为）之间的关系。方法：我们从芝加哥社区人类发展项目中随机抽取出生队列成员，于1995年至1997年招募，年龄为17岁，并与公共卫生部的儿童血液检测结果相匹配。我们使用普通最小二乘回归，粗精确匹配和工具变量来评估儿童期平均血铅水平与青春期冲动，焦虑或抑郁和体重指数之间的关系。所有模型都针对相关的个人、家庭和社区特征进行了调整。结果校正后，儿童平均血铅水平每升高1微克/分升，（95%置信区间[CI] = 0.01，0.12）和0.09（95% CI = 0.03，0.16）SD增加，0.37（95% CI = 0.11，0.64）青少年冲动、焦虑或抑郁和体重指数分别增加1分，普通最小二乘回归。匹配和工具变量策略的结果非常相似。结论儿童期铅暴露损害青少年的幸福感，与种族和阶级不平等的持久性的影响，考虑到初始暴露的结构模式。
Objectives To assess the relationships between childhood lead exposure and 3 domains of later adolescent health: mental, physical, and behavioral. Methods We followed a random sample of birth cohort members from the Project on Human Development in Chicago Neighborhoods, recruited in 1995 to 1997, to age 17 years and matched to childhood blood test results from the Department of Public Health. We used ordinary least squares regression, coarsened exact matching, and instrumental variables to assess the relationship between average blood lead levels in childhood and impulsivity, anxiety or depression, and body mass index in adolescence. All models adjusted for relevant individual, household, and neighborhood characteristics. Results After adjustment, a 1 microgram per deciliter increase in average childhood blood lead level significantly predicts 0.06 (95% confidence interval [CI] = 0.01, 0.12) and 0.09 (95% CI = 0.03, 0.16) SD increases and a 0.37 (95% CI = 0.11, 0.64) point increase in adolescent impulsivity, anxiety or depression, and body mass index, respectively, following ordinary least squares regression. Results following matching and instrumental variable strategies are very similar. Conclusions Childhood lead exposure undermines adolescent well-being, with implications for the persistence of racial and class inequalities, considering structural patterns of initial exposure.
铅暴露对学龄前儿童行为问题的影响。
影响因子：
12.7
作者：
Wasserman,GA;Staghezza-Jaramillo,B;Shrout,P;Popovac,D;Graziano,J
通讯作者：
Graziano,J