A systematic review of the literature on disorders of sleep and wakefulness in Parkinson's disease from 2005 to 2015.
A systematic review of the literature on disorders of sleep and wakefulness in Parkinson's disease from 2005 to 2015.
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DOI：
10.1016/j.smrv.2016.08.001
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发表时间：
2017-10
影响因子：
10.5
通讯作者：
Videnovic A
中科院分区：
文献类型：
--
作者：
Chahine LM;Amara AW;Videnovic A
睡眠障碍是帕金森病（PD）最常见的非运动表现之一，对生活质量有显著的负面影响。虽然PD中的睡眠障碍与一般人群中发生的睡眠障碍具有大多数特征，但在诊断，管理和影响方面，该患者人群有几个特定的考虑因素。对这些疾病的现有研究正在迅速扩大，但许多问题仍然没有答案。因此，我们对2005 - 2015年发表的关于PD患者以下睡眠和觉醒障碍的文献进行了系统综述：REM睡眠行为障碍、失眠、失眠、不宁腿综合征和周期性肢体运动、睡眠呼吸障碍、白天过度嗜睡和昼夜节律障碍。我们讨论了这些疾病的流行病学，病因学，临床意义，相关特征，评估措施和管理。详细介绍了用于治疗PD运动和非运动症状的药物对睡眠的影响。此外，我们建议需要进一步研究的领域。
Sleep disorders are among the most common non-motor manifestations in Parkinson’s disease (PD) and have a significant negative impact on quality of life. While sleep disorders in PD share most characteristics with those that occur in the general population, there are several considerations specific to this patient population regarding diagnosis, management, and implications. The available research on these disorders is expanding rapidly, but many questions remain unanswered. We thus conducted a systematic review of the literature published from 2005-2015 on the following disorders of sleep and wakefulness in PD: REM sleep behavior disorder, insomnia, nocturia, restless legs syndrome and periodic limb movements, sleep disordered breathing, excessive daytime sleepiness, and circadian rhythm disorders. We discuss the epidemiology, etiology, clinical implications, associated features, evaluation measures, and management of these disorders. The influence on sleep of medications used in the treatment of motor and non-motor symptoms of PD is detailed. Additionally, we suggest areas in need of further research.