Correlates and predictors of adherence to highly active antiretroviral therapy: Overview of published literature
Correlates and predictors of adherence to highly active antiretroviral therapy: Overview of published literature
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DOI：
10.1097/00126334-200212153-00007
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发表时间：
2002-12-15
影响因子：
3.6
通讯作者：
Antinori, A
中科院分区：
文献类型：
--
作者：
Ammassari, A;Trotta, MP;Antinori, A
与药物依从性相关的因素的知识可以帮助艾滋病毒临床医生在需要干预的目标人群，设计这些干预措施，并帮助研究人员计划的依从性研究。这篇综述总结了20项研究的结果，调查的问题，最佳的高效抗逆转录病毒治疗（HAART）坚持的障碍。只有少数决定因素始终与不依从性相关。症状和药物不良反应、心理困扰、缺乏社会或家庭支持、HAART方案的复杂性、患者自我效能低和治疗不便是与不依从性最相关的因素。关于依从性与以下变量的关系，存在不一致的结果：社会人口学特征、药物滥用、抑郁症状、生活质量、CD4（+）细胞计数、治疗知识和信念、患者对医疗保健的满意度以及患者与提供者的关系。由于现有研究的一些局限性，很难综合各种因素与HAART依从性的关系。这些局限性涉及依从性的测量、依从性的相关性和预测因子的评估、研究人群和研究设计。
Knowledge of factors associated with medication adherence could help HIV clinicians to target persons in need of intervention, design these interventions, and help researchers to plan studies of adherence. This review summarizes the results of 20 studies investigating the issue of barriers to optimal highly active antiretroviral therapy (HAART) adherence. Only a few determinants were consistently associated with nonadherence. Symptoms and adverse drug effects, psychologic distress, lack of social or family support, complexity of the HAART regimen, low patient self-efficacy, and inconvenience of treatment were the factors most consistently associated with nonadherence. There were inconsistent findings regarding the relationship of adherence,and the following variables: sociodemographic characteristics, substance abuse, depressive symptoms, quality of life, CD4(+) cell count, knowledge and beliefs about treatment, patients' satisfaction with health care, and patient-provider relationship. A synthesis of findings relating various factors to adherence to HAART is difficult to reach because of several limitations of the existing body of research. These limitations concern the measurement of adherence, the assessment of correlates and predictors of adherence, the study population, and the study design.