Effect of human pancreatic polypeptide and its C-terminal hexapeptide on pancreatic secretion in man and in the dog.
Effect of human pancreatic polypeptide and its C-terminal hexapeptide on pancreatic secretion in man and in the dog.
复制标题
人胰多肽及其C端六肽对人和狗胰腺分泌的影响。
DOI：
10.3109/00365528209182074
复制
发表时间：
1982
影响因子：
1.9
通讯作者：
A. V. Schally
中科院分区：
文献类型：
--
作者：
S. Konturek;C. Meyers;N. Kwiecień;W. Obtułowicz;J. Tasler;J. Oleksy;B. Kopp;D. H. Coy;A. V. Schally
人胰多肽(HPP)及其C端六肽(HP-PP)在促胰液素的次极量刺激下，以不同剂量静脉注射给健康人和慢性胰瘘犬。用放射免疫法测定血浆PP水平，监测胰腺血流量、碳酸氢盐排出量和蛋白排出量。PP和HP-PP在人类中不影响分泌诱导的容量流动或碳酸氢盐的分泌，但在最高剂量时，它会减少蛋白质产量。在狗身上，HPP和HP-PP均呈剂量依赖性地抑制胰腺的体积流量和碳酸氢盐和蛋白质的输出。在这些实验中，HPP的输注剂量与血浆PP水平的增加呈线性相关。外源性HPP的剂量对胰腺分泌的抑制作用与肉餐后通常看到的血浆PP浓度没有显着差异。提示HPP对人和犬胰腺外分泌的作用有显著差异，PP可能是人胰腺蛋白质分泌的生理性抑制因子，也是狗碳酸氢盐和蛋白质分泌的生理抑制因子，其C端六肽可模拟HPP对胰腺外分泌的作用。
Human pancreatic polypeptide (HPP) and its C-terminal hexapeptide (HP-PP) were infused intravenously in graded doses into healthy human subjects and dogs with chronic pancreatic fistula during submaximal stimulation with secretin. Plasma levels of PP were measured by radioimmunoassay, and pancreatic volume flow and bicarbonate and protein outputs were monitored. PP and HP-PP in humans did not affect secretion-induced volume flow or bicarbonate secretion, but at the highest doses it reduced the protein outputs. In dogs both HPP and HP-PP inhibited dose-dependently the pancreatic volume flow and bicarbonate and protein outputs. There was a linear correlation between the dose of HPP infused and the increments in plasma PP levels in these experiments. The inhibition of pancreatic secretion occurred at doses of exogenous HPP which produced blood plasma PP concentrations not significantly different from those normally seen after a meat meal. We conclude that there is a marked difference in the effect of HPP on the exocrine pancreas in man and the dog, that PP may play a role as a physiological inhibitor of pancreatic protein secretion in man and of both bicarbonate and protein secretion in the dog, and that the effect of HPP on the exocrine pancreas can be mimicked by its C-terminal hexapeptide.