Tetraspanins in the immune response against cancer
Tetraspanins in the immune response against cancer
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DOI：
10.1016/j.imlet.2011.03.010
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发表时间：
2011-08-30
影响因子：
4.4
通讯作者：
van Spriel, Annemiek B.
中科院分区：
文献类型：
--
作者：
Veenbergen, Sharon;van Spriel, Annemiek B.
免疫系统在防御癌症中的作用，一个被称为肿瘤免疫监视的过程，已经被广泛研究。越来越多的证据表明，免疫细胞质膜中蛋白质和脂质的分子组织至关重要。四跨膜蛋白在所有哺乳动物细胞的质膜中表达，并且在伴侣分子空间组织成四跨膜蛋白富集的微结构域中起重要作用。现在已经确定四跨膜蛋白相互作用以及与多种关键白细胞蛋白，包括免疫受体，整合素和信号分子相互作用。这些四跨膜蛋白-伴侣蛋白相互作用控制几个基本的细胞过程，其在免疫细胞中涉及抗原呈递、运动性、增殖和抗体产生。我们认为四跨膜蛋白微区组成的差异决定了单个四跨膜蛋白促进或抑制免疫应答的能力。在这篇综述中，我们讨论了四跨膜蛋白在免疫细胞中的功能的新见解，并描述了这可能如何控制抗肿瘤免疫。(C)2011爱思唯尔有限公司版权所有。
The role of the immune system in the defense against cancer, a process termed tumor immunosurveillance, has been extensively studied. Evidence is accumulating that the molecular organization of proteins and lipids in the plasma membrane of immune cells is of critical importance. Tetraspanin proteins are expressed in the plasma membrane of all mammalian cells and play an important role in the spatial organization of partner molecules into tetraspanin-enriched microdomains. It is now well established that tetraspanins interact with one another as well as with a diverse array of key leukocyte proteins, including immune receptors, integrins, and signaling molecules. These tetraspanin-partner protein interactions control several fundamental cellular processes, which in immune cells involve antigen presentation, motility, proliferation and antibody production. We propose that differences in the tetraspanin rnicrodomain composition account for the abilities of individual tetraspanins to either promote or suppress immune responses. In this review, we discuss novel insights into tetraspanin function in immune cells, and describe how this may control anti-tumor immunity. (C) 2011 Elsevier B.V. All rights reserved.