Immunocytochemical localization of placental lactogen and chorionic gonadotropin in the normal placenta and trophoblastic tumors, with emphasis on intermediate trophoblast and the placental site trophoblastic tumor.
Immunocytochemical localization of placental lactogen and chorionic gonadotropin in the normal placenta and trophoblastic tumors, with emphasis on intermediate trophoblast and the placental site trophoblastic tumor.
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胎盘催乳素和绒毛膜促性腺激素在正常胎盘和滋养层肿瘤中的免疫细胞化学定位，重点是中间滋养层和胎盘部位滋养层肿瘤。
DOI：
10.1097/00004347-198403010-00009
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Scully,RE
中科院分区：
文献类型：
--
作者：
Kurman,RJ;Young,RH;Norris,HJ;Main,CS;Lawrence,WD;Scully,RE
本报告介绍了胎盘部位滋养细胞肿瘤、葡萄胎和绒毛膜癌中人绒毛膜促性腺激素 (hCG) 和人胎盘催乳素 (hPL) 免疫细胞化学定位的初步观察结果，并将这些结果与不同发育阶段胎盘的类似免疫细胞化学分析结果进行了比较。除了细胞滋养层 (CT) 和合体滋养层 (ST) 之外，正常妊娠期间和滋养层疾病中还存在第三种形式的滋养层，称为“中间滋养层”(IT)。中间滋养层细胞是单核细胞，比CT大，并且含有更丰富的嗜酸性细胞质，导致与ST部分相似。中间滋养层具有与 CT 和 ST 不同的独特的免疫细胞化学特征。 hPL 和 hCG 在 IT 和 ST 中的定位随胎盘年龄、滋养细胞肿瘤的类型以及每一类肿瘤中的一个样本到另一个样本的不同而变化。合体滋养层可能含有大量这两种激素，而IT主要含有hPL，局部含有hCG。细胞滋养层缺乏 hCG 和 hPL，但绒毛膜癌除外，绒毛膜癌可能显示 hCG 局灶性弱染色。 hCG 和 hPL 的免疫细胞化学鉴定已被证明有助于阐明滋养细胞肿瘤的组织发生，并且对于确定其诊断和确定其预后也可能有价值。
This report presents preliminary observations on the immunocytochemical localization of human chorionic gonadotropin (hCG) and human placental lactogen (hPL) in placental site trophoblastic tumors, hydatidiform moles, and choriocarcinomas and compares the findings with those of a similar immunocytochemical analysis of the placenta at various stages of development. In addition to cytotrophoblast (CT) and syncytiotrophoblast (ST), a third form of trophoblast designated “intermediate trophoblast”(IT) is present during normal pregnancy and in trophoblastic disease. Intermediate trophoblastic cells are mononucleate, larger than CT, and contain more abundant eosinophilic cytoplasm, resulting in a partial resemblance to ST. Intermediate trophoblast has distinctive immunocytochemical features that distinguish it from CT and ST. The localization of hPL and hCG in both IT and ST varies with the age of the placenta, with the type of trophoblastic neoplasm, and from one specimen to another within each category of tumor. Syncytiotrophoblast may contain both hormones in large amounts, whereas IT contains hPL predominantly and hCG focally. Cytotrophoblast is devoid of hCG and hPL except in choriocarcinoma, which may show focal weak staining for hCG. Immunocytochemical identification of hCG and hPL has proved helpful in clarifying the histogenesis of trophoblastic neoplasms and may also be of value in establishing their diagnosis and in determining their prognosis.