Separate worlds set to collide: Smallpox, vaccinia virus vaccination, and human immunodeficiency virus and acquired immunodeficiency syndrome
Separate worlds set to collide: Smallpox, vaccinia virus vaccination, and human immunodeficiency virus and acquired immunodeficiency syndrome
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DOI：
10.1086/375823
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发表时间：
2003-08-01
影响因子：
11.8
通讯作者：
Isaacs, SN
中科院分区：
文献类型：
--
作者：
Amorosa, VK;Isaacs, SN
对生物恐怖分子可能释放天花的担忧导致了建议一些卫生保健提供者接种天花疫苗的政策，在不久的将来，疫苗可能会在自愿的基础上提供给普通人群。天花病毒（天花病毒）和天花疫苗（牛痘病毒）都会对感染人类免疫缺陷病毒（HIV）的人产生重大影响。鉴于获得性免疫缺陷综合征人群和实体器官和骨髓移植导致的免疫抑制人群在天花流行的日子里并不存在，我们将推测天花如何在免疫缺陷患者中出现，我们将回顾天花疫苗在HIV感染宿主中预期的不良事件。
Concerns about the possible release of smallpox by bioterrorists has led to policies that recommend smallpox vaccination of some health care providers, and, in the near future, the vaccine may become available to the general population on a voluntary basis. Both smallpox virus ( variola virus) and the smallpox vaccine ( vaccinia virus) will have a significant impact on people infected with human immunodeficiency virus (HIV). Given that populations with acquired immunodeficiency syndrome and populations with immunosuppressed conditions due to solid organ and bone marrow transplantation were not present in the days when smallpox was prevalent, we will speculate on how smallpox might present in immunodeficient patients, and we will review the adverse events expected from the smallpox vaccine in hosts with HIV infection.