The Role of Ki-67 Index Cut-off of 55% and Differentiation in Redefining NET and NEC for Grade 3 Gastrointestinal Neuroendocrine Neoplasms
The Role of Ki-67 Index Cut-off of 55% and Differentiation in Redefining NET and NEC for Grade 3 Gastrointestinal Neuroendocrine Neoplasms
复制标题
%20Role%20of%20Ki-67%20Index%20Cut-off%20of%2055%%20和%20Differentiation%20in%20重新定义%20NET%20和%20NEC%20for%20Grade%203%20胃肠%20神经内分泌%20肿瘤
DOI：
10.1007/s11605-020-04651-1
复制
发表时间：
2020-06
影响因子：
3.2
通讯作者：
Chen Jie
中科院分区：
文献类型：
--
作者：
Shi Huiying;Chen Luohai;Meng Lingjun;Zhang Qin;Lin Yuan;Lin Rong;Chen Jie
2017年，世界卫生组织（WHO）将3级（G3）胰腺神经内分泌肿瘤定义为分化良好，Ki-67标记指数通常在20%至55%之间。1 G3胃肠胰腺神经内分泌肿瘤（GEP-NEN）随后根据WHO 2019年修订的分类方案被分类为神经内分泌肿瘤（NET）和神经内分泌癌（NEC）。2然而，修订后的系统没有规定G3胃NET（g-NET）和G3肠NET的Ki-67上限。因此，本研究旨在探索胃肠道（GI）NEN（GI-NEN）中G3 NET和G3 NEC概念的Ki-67上限，并检查分类（2019）对G3 GI-NEN患者预测预后的有效性。
In 2017, the World Health Organization (WHO) defined grade 3 (G3) pancreatic neuroendocrine tumor as well-differentiated with a Ki-67 labeling index, typically between 20 and 55%. 1 G3 gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) were then classified as neuroendocrine tumors (NETs) and neuroendocrine carcinomas (NECs) under the revised classification scheme of WHO in 2019. 2 Nevertheless, the revised systems did not specify the upper cut-off of Ki-67 for G3 gastric NETs (g-NETs) and G3 intestinal NETs. The present study, therefore, aimed to explore an upper cut-off of Ki-67 for the concept of G3 NETs and G3 NECs in gastrointestinal (GI) NENs (GI-NENs) and to check the validity of classification (2019) for the predictive prognosis of G3 GI-NENs patients.
影响因子：
20.4
作者：
Brims, Fraser J. H.;Meniawy, Tarek M.;Nowak, Anna K.
通讯作者：
Nowak, Anna K.
基于ADC图纹理分析预测脑膜瘤WHO分级的诊断价值：决策树和决策森林的尝试
影响因子：
5.9
作者：
Lu, Yiping;Liu, Li;Yin, Bo
通讯作者：
Yin, Bo
DOI：
--
发表时间：
2017-06
期刊：
--
影响因子：
--
作者：
R. Lloyd;R. Osamura;G. Klöppel;J. Rosai
通讯作者：
R. Lloyd;R. Osamura;G. Klöppel;J. Rosai