Connectome analysis of functional and structural hemispheric brain networks in major depressive disorder
Connectome analysis of functional and structural hemispheric brain networks in major depressive disorder
复制标题
重度抑郁症功能和结构半球大脑网络的连接组分析
DOI：
10.1038/s41398-019-0467-9
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发表时间：
2019-04-12
影响因子：
6.8
通讯作者：
Wang, Jinhui
中科院分区：
文献类型：
--
作者：
Jiang, Xueyan;Shen, Yuedi;Wang, Jinhui
神经影像学研究表明，重度抑郁症 (MDD) 的全脑网络功能和结构均出现拓扑破坏。这项研究检查了这两类网络之间的常见和特定改变，以及这些改变是否在两个半球中存在差异。从 35 名 MDD 患者和 35 名健康对照中收集了多模态 MRI 数据，对他们的功能和结构半球网络进行了构建、表征和比较。我们发现，重度抑郁症患者的功能性大脑网络在多个层面上发生了深刻的改变，而结构性大脑网络基本上完好无损。具体来说，功能改变包括半球内（左和右）和半球间（异位）功能连接的减少；两个半球网络的局部、全局和标准化全局效率下降；左半球网络的归一化局部效率提高；背外侧额上回、前扣带回和海马的半球内整合和半球间通讯减少。关于半球不对称性，在功能网络和结构网络之间观察到了很大程度上相似的模式：右半球过度连接并且整体上比左半球更有效；枕叶和部分区域表现出向左不对称，额叶和颞叶部位在局部区域连通性方面表现出向右偏侧化。最后，半球内连接的功能-结构耦合显着降低，并与患者疾病的严重程度相关。总体而言，这项研究证明了 MDD 中模态和半球依赖性且不变的网络改变，这有助于理解这种疾病中整合功能障碍的复杂和特征模式。
Neuroimaging studies have shown topological disruptions of both functional and structural whole-brain networks in major depressive disorder (MDD). This study examined common and specific alterations between these two types of networks and whether the alterations were differentially involved in the two hemispheres. Multimodal MRI data were collected from 35 MDD patients and 35 healthy controls, whose functional and structural hemispheric networks were constructed, characterized, and compared. We found that functional brain networks were profoundly altered at multiple levels, while structural brain networks were largely intact in patients with MDD. Specifically, the functional alterations included decreases in intra-hemispheric (left and right) and inter-hemispheric (heterotopic) functional connectivity; decreases in local, global and normalized global efficiency for both hemispheric networks; increases in normalized local efficiency for the left hemispheric networks; and decreases in intra-hemispheric integration and inter-hemispheric communication in the dorsolateral superior frontal gyrus, anterior cingulate gyrus and hippocampus. Regarding hemispheric asymmetry, largely similar patterns were observed between the functional and structural networks: the right hemisphere was over-connected and more efficient than the left hemisphere globally; the occipital and partial regions exhibited leftward asymmetry, and the frontal and temporal sites showed rightward lateralization with regard to regional connectivity profiles locally. Finally, the functional–structural coupling of intra-hemispheric connections was significantly decreased and correlated with the disease severity in the patients. Overall, this study demonstrates modality- and hemisphere-dependent and invariant network alterations in MDD, which are helpful for understanding elaborate and characteristic patterns of integrative dysfunction in this disease.