Clinical and experimental evaluation of the effect of Khat-induced myocardial infarction.
Clinical and experimental evaluation of the effect of Khat-induced myocardial infarction.
复制标题
阿拉伯茶诱发心肌梗死作用的临床和实验评价。
作者：
H. Alkadi;M. A. Noman;A. K. al;Fuad S Al;Y. A. Raja’a
目的
评估也门Khat诱导的心肌梗死（MI）的影响。
方法
本研究收集了2001年期间入住也门萨那市Al-Thawra医院的120名MI患者和120名志愿者对照。另一方面，我们使用48只成年雄性家兔进行本研究，并将其分为8组。每组6只动物; I组为正常对照组，II组静脉滴注肾上腺素60 g/kg，III、IV组静脉滴注阿拉伯茶1g/kg，每日1次，共2个月，V、VI组静脉滴注阿拉伯茶1g/kg，每日3次，共2个月，VII、VIII组静脉滴注阿拉伯茶提取物1g/kg，最后一次给药后4小时，对第IV、VI和VIII组静脉输注阿拉伯茶和肾上腺素60 g/kg。动物被斩首处死。每只家兔采集血样，测定其肌酸激酶同工酶（CK-MB）、乳酸脱氢酶（LDH）和血清谷草转氨酶。此外，快速解剖心脏用于组织病理学研究。
结果
79%的MI患者咀嚼阿拉伯茶，只有20.8%的患者不咀嚼阿拉伯茶。实验研究表明，阿拉伯茶在1克/公斤的剂量，每天3次，2个月，阿拉伯茶提取物相当于1克/公斤静脉输注单独和与肾上腺素60克/公斤静脉输注相结合显着增加心肌酶（CK-MB，天冬氨酸转氨酶，LDH），此外，组织病理学研究显示，为同一组的多个地区的梗死。
结论
目前的研究表明，咀嚼阿拉伯茶可能被认为是发生心肌梗死的一个危险因素，特别是在易患心肌梗死的人群中。因此，建议有任何心血管问题的人应避免咀嚼阿拉伯茶。
OBJECTIVE
To evaluate the effect of Khat-induced myocardial infarction (MI) in Yemen.
METHODS
One hundred and twenty patients with MI, admitted to Al-Thawra Hospital, Sana'a City, Yemen, during the year 2001 and 120 volunteer controls were collected for this study. On the other hand, we used 48 adult male rabbits for this study and divided it into 8 groups. Each group was consist of 6 animals; group I was used as normal control, group II was given adrenaline 60 g/kg intravenous infusion, group III and IV were given Khat 1g/kg once daily for 2 months, group V and VI were given Khat 1g/kg 3 times daily for 2 months, group VII and VIII were given Khat extract equivalent to 1g/kg intravenous infusion, 4 hours after the last dose of Khat and adrenaline 60 g/kg intravenous infusion was given to groups IV, VI and VIII. The animals were killed by decapitation. Blood samples were collected from each rabbit for determination of their creatinine kinase-iso enzyme (CK-MB) lactate dehydrogenase (LDH) and serum glutamic-oxaloacetic transaminase enzymes. Also, hearts were dissected out rapidly for histopathological study.
RESULTS
Seventy-nine percent of patients with MI were Khat chewers and only 20.8% were non-Khat chewers. Experimental study shows that Khat in a dose of 1g/kg 3 times a day for 2 months, Khat extract equivalent to 1g/kg intravenous infusion alone and in combination with adrenaline 60 g/kg intravenous infusion significantly increased cardiac enzymes (CK-MB, aspartate transaminase, LDH), also, the histopathological study for the same groups revealed multiple areas of infarction.
CONCLUSION
The present study has demonstrated that Khat chewing may be considered as a risk factor for the occurrence of MI especially in persons who are susceptible to the disease. It is therefore, recommended that Khat chewing should be avoided in persons who have any cardiovascular problems.
心肌梗死期间的心肌保护：溶栓治疗期间的药物保护。
DOI：
10.1016/0002-9149(90)90124-j
发表时间：
1990
期刊：
The American journal of cardiology
影响因子：
--
作者：
Willerson,JT;Buja,LM
通讯作者：
Buja,LM
使用 DNA 扩增方法进行自身免疫性疾病的临床诊断。
影响因子：
2.7
作者：
Fox,RI;Dotan,I;Compton,T;Fei,HM;Hamer,M;Saito,I
通讯作者：
Saito,I