EFFECT OF HUMAN INTERFERON PREPARATIONS ON LYMPHOBLASTOGENESIS IN DOWNS-SYNDROME
EFFECT OF HUMAN INTERFERON PREPARATIONS ON LYMPHOBLASTOGENESIS IN DOWNS-SYNDROME
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DOI：
10.1038/267165a0
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发表时间：
1977-01-01
期刊：
影响因子：
64.8
通讯作者：
TAN, YH
中科院分区：
文献类型：
--
作者：
CUPPLES, CG;TAN, YH
人干扰素最典型的特性是其抗病毒 (AV) 和细胞增殖抑制 (CMI) 活性，以一种无法解释的方式由 21 号染色体上的基因控制（参考文献 1-4；14-16）。人类和动物干扰素具有多种免疫抑制作用5-10，其中包括在体外抑制活化淋巴细胞中的DNA合成11。使用来自正常受试者（二体性 21）和其他唐氏综合症患者（三体性 21）的有丝分裂原和抗原刺激的淋巴细胞，我们发现后者的 DNA 合成在更大程度上受到成纤维细胞和白细胞干扰素的抑制。我们认为这一特性也受到 21 号染色体上的基因的调节。
THE best characterised properties of human interferon, its antiviral (AV) and cell multiplication inhibitory (CMI) activities, are controlled, in an unexplained manner, by genes on chromosomes 21 (refs 1–4; 14–16). Human and animal interferons have various immunosuppressive effects5–10, among them the inhibitionin vitroof DNA synthesis in activated lymphocytes11. Using mitogen- and antigen-stimulated lymphocytes from normal subjects (disomic 21) and others with Down's syndrome (trisomic 21), we have found that DNA synthesis is inhibited to a greater degree in the latter by both fibroblastoid and leukocyte interferons. We suggest that this property is also regulated by genes on chromosome 21.