A new Speedy/RINGO protein may help regulate male meiosis.
A new Speedy/RINGO protein may help regulate male meiosis.
复制标题
一种新的 Speedy/RINGO 蛋白可能有助于调节雄性减数分裂。
DOI：
10.1038/aja.2011.30
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发表时间：
2011
影响因子：
2.9
通讯作者：
Ward,WSteven
中科院分区：
文献类型：
--
作者：
Yamazaki,Yukiko;Ward,WSteven
生殖生物学虽然被视为一个专业研究领域，但拥有许多独特的生物学模型，可以深入了解许多不同细胞类型共享的细胞过程的调节。最著名的例子是细胞周期蛋白的发现及其在非洲爪蟾卵母细胞细胞周期调节中的作用。 1-4 减数分裂是该领域的一个方面，它为细胞周期调控和染色质结构的研究提供了一个重要的窗口。减数分裂仅发生在睾丸和卵巢中，并且仅发生在最终产生精原细胞和卵母细胞的生殖细胞中。 5 在本期中，Cheng 及其同事6 提供的数据表明，他们最初在大鼠睾丸中发现的一种新蛋白质（称为 LM23）对于精子发生中减数分裂的调节至关重要。 LM23 是调节细胞周期蛋白的 Speedy/RINGO 蛋白家族的成员，这也许是合适的。 7Speedy/RINGO 家族至少包含从酵母到人类的八个成员，并且都共享一个称为 Speedy/RINGO 框的中心区域。 7 这些蛋白质通过直接结合 CDK1/2 参与细胞周期、DNA 损伤反应和进入减数分裂。 Liu及其同事最初通过差异显示将LM23鉴定为一种基因，该基因在大鼠睾丸中正在经历减数分裂的精母细胞中高度表达。 8 在这份报告中，他们证明了 LM23 具有与小鼠 Speedy/RINGO A 97% 同源性的 Speedy/RINGO 盒。目前，研究培养中雄性生殖细胞减数分裂成熟的模型很少，而且现有的模型在技术上都存在缺陷。
Reproductive biology, although seen as a specialty study area, has many unique biology models that offer insight into the regulation of cellular processes that are shared by many different cell types. The most celebrated example of this was the discovery of the cyclins and their role in cell cycle regulation in Xenopus oocytes. 1–4 Meiosis is one such aspect of this field that presents an important window for the study of both cell cycle regulation and chromatin structure. Meiosis only occurs in the testis and ovaries, and only in the germ cells that eventually produce spermatogonia and oocytes. 5 In this issue, Cheng and colleagues6 present data to suggest that a novel protein they originally identified in the rat testis, called LM23, is crucial for the regulation of meiosis in spermatogenesis. It is perhaps fitting that LM23 is a member of a family of proteins called Speedy/RINGO that regulate cyclins. 7The Speedy/RINGO family contains at least eight member from yeast to humans, and all share a central region called the Speedy/RINGO box. 7 These proteins participate in the cell cycle, DNA damage response and entry into meiosis, through direct binding to CDK1/2. Liu and colleagues originally identified LM23 as a gene by differential display that was very highly expressed in rat testis in the cells that are undergoing meiosis, spermatocytes. 8 In this report, they demonstrated that LM23 has a Speedy/RINGO box that is 97% homologous to the mouse Speedy/RINGO A. At present, there are few models to study meiotic maturation of male germ cells in culture, and those that are available are technically