The clinical relevance of genetic susceptibility to osteoarthritis
The clinical relevance of genetic susceptibility to osteoarthritis
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DOI：
10.1016/j.berh.2009.08.005
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发表时间：
2010-02-01
影响因子：
5.2
通讯作者：
Spector, Tim D.
中科院分区：
文献类型：
--
作者：
Valdes, Ana M.;Spector, Tim D.
骨关节炎是导致老年人残疾的主要原因，但目前的治疗方法不足以预防该疾病的发生和进展。人类遗传学研究已经确定了参与信号级联的分子，这些分子对于关节部件的病理学很重要。这些包括骨形态发生蛋白（BMP）信号传导、无翅型信号传导和甲状腺途径以及细胞凋亡相关分子。越来越多的证据表明，与细胞因子产生、前列腺素和花生四烯酸代谢相关的炎症分子也与骨关节炎的易感性有关。所有这些途径都可能是药物干预的目标。遗传变异也会影响骨关节炎引起的疼痛，突出显示缓解疼痛的分子机制。此外，遗传市场的组合可用于识别骨关节炎高风险和全关节置换术失败风险的个体，这应有助于预防和疾病管理策略的应用。 (C) 2009 Elsevier Ltd. 保留所有权利。
Osteoarthritis is a major musculoskeletal cause of disability in the elderly, but current therapeutic approaches are insufficient to prevent initiation and progression of the disease. Genetic studies in humans have identified molecules involved in signalling cascades that are important for the pathology of the joint components. These include the bone morphogenetic protein (BMP) signalling, the wingless-type signalling and the thyroid pathway as well as apoptotic-related molecules. There is emerging evidence indicating that inflammatory molecules related to cytokine production, prostaglandin and arachidonic acid metabolism are also involved ill Susceptibility to osteoarthritis. All of these pathways are likely targets for pharmacological intervention. Genetic variation also affects pain due to osteoarthritis highlighting molecular mechanisms for pain relief. Moreover, combinations of genetic markets can be used to identify individuals at high risk of osteoarthritis and risk of total joint arthroplasty failure, which should facilitate the application of preventive and disease management strategies. (C) 2009 Elsevier Ltd. All rights reserved.