Immunohistochemical detection of the c‐erbB‐2 proto‐oncogene product in normal, benign and malignant cartilage tissues
Immunohistochemical detection of the c‐erbB‐2 proto‐oncogene product in normal, benign and malignant cartilage tissues
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正常、良性和恶性软骨组织中c-erbB-2原癌基因产物的免疫组织化学检测
DOI：
10.1111/j.1365-2559.1989.tb03042.x
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发表时间：
1989
期刊：
影响因子：
6.4
通讯作者：
Mechthild Salzer
中科院分区：
文献类型：
--
作者：
Fritz Wrba;W. J. Gullick;H. Fertl;G. Amann;Mechthild Salzer
良性和恶性软骨肿瘤以及正常软骨用抗体进行化学染色，该抗体针对来自c-erbB-2蛋白序列的合成肽。23例软骨肉瘤中18例阳性，1例骨软骨瘤阳性。正常和良性肿瘤软骨组织均为阴性。可以得出结论，c-erbB-2蛋白的表达可能有助于软骨肉瘤的细胞转化;目前还不清楚软骨肉瘤中c-erbB-2蛋白的表达是否是具有不同预后意义的亚群的特征。
Benign and malignant cartilage tumours as well as normal cartilage were stained immunohistochemically with antibodies raised to a synthetic peptide from the sequence of the c‐erbB‐2 protein. Positive staining was present in 18/23 of the chondrosarcomas and in one case of osteochondroma. Normal and benign neoplastic cartilage tissues revealed negative results. It is concluded that expression of the c‐erbB‐2 protein may contribute to cell transformation in chondrosarcomas; it is not apparent whether the expression of c‐erbB‐2 protein in chondrosarcomas characterizes a subpopulation of different prognostic significance.
影响因子：
56.9
作者：
SLAMON, DJ;CLARK, GM;MCGUIRE, WL
通讯作者：
MCGUIRE, WL