Neurobiology, Stem Cell Biology, and Immunology: An Emerging Triad for Understanding Tissue Homeostasis and Repair.
Neurobiology, Stem Cell Biology, and Immunology: An Emerging Triad for Understanding Tissue Homeostasis and Repair.
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DOI：
10.1146/annurev-cellbio-120320-032429
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发表时间：
2022-10-06
影响因子：
11.3
通讯作者：
Hsu, Ya-Chieh
中科院分区：
文献类型：
--
作者：
Scott-Solomon, Emily;Hsu, Ya-Chieh
关键词：
周围神经系统 (PNS) 赋予生物体感知和响应动态世界的非凡能力。新的证据表明，三七总皂甙还通过将局部变化与有机体和环境变化相结合来参与组织稳态和修复。在这里，我们深入总结了研究结果，描述了周围神经在稳定状态条件下调节干细胞行为和免疫反应以及响应损伤和胁迫方面的不同作用，特别关注皮肤和造血系统。这些例子展示了阐明神经干细胞和神经免疫细胞相互作用如何提供一个概念框架，将组织生物学和局部免疫与全身身体变化联系起来，以满足不同的需求。他们还展示了这些相互作用的变化如何在压力、衰老、癌症和炎症中体现，以及如何利用这些发现来指导新疗法的开发。
The peripheral nervous system (PNS) endows organisms with the remarkable ability to sense and respond to our dynamic world. Emerging evidence shows the PNS also participates in tissue homeostasis and repair by integrating local changes with organismal and environmental changes. Here, we provide an in-depth summary of findings delineating the diverse roles of peripheral nerves in modulating stem cell behaviors and immune responses under steady state conditions and in response to injury and duress, with a specific focus on the skin and in the hematopoietic system. These examples showcase how elucidating neuro-stem cell and neuro-immune cell interactions provides a conceptual framework that connects tissue biology and local immunity with systemic bodily changes to meet varying demands. They also demonstrate how changes in these interactions can manifest in stress, aging, cancer, and inflammation, as well as how these findings can be harnessed to guide the development of new therapeutics.
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DOI：
10.1073/pnas.0700293104
发表时间：
2007-03-20
影响因子：
11.1
作者：
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通讯作者：
Roth, Bryan L.
影响因子：
64.5
作者：
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影响因子：
64.8
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通讯作者：
Fuchs, Elaine
DOI：
10.1523/jneurosci.6451-10.2011
发表时间：
2011-03-30
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Cavanaugh DJ;Chesler AT;Jackson AC;Sigal YM;Yamanaka H;Grant R;O'Donnell D;Nicoll RA;Shah NM;Julius D;Basbaum AI
通讯作者：
Basbaum AI
影响因子：
23.9
作者：
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通讯作者：
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