Medawar's PostEra: Galectins Emerged as Key Players During Fetal-Maternal Glycoimmune Adaptation.
Medawar's PostEra: Galectins Emerged as Key Players During Fetal-Maternal Glycoimmune Adaptation.
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DOI：
10.3389/fimmu.2021.784473
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发表时间：
2021
影响因子：
7.3
通讯作者：
Blois SM
中科院分区：
文献类型：
--
作者：
Menkhorst E;Than NG;Jeschke U;Barrientos G;Szereday L;Dveksler G;Blois SM
凝集素-葡聚糖的相互作用，特别是由半乳糖凝集素家族介导的相互作用，调节着成功妊娠所需的许多过程。在过去的几十年里，从体外和体内实验中收集到的越来越多的证据表明，Galectin家族的成员特异性地与细胞内和膜上结合的碳水化合物配体结合，调节血管生成、耐受胎儿半同种异体移植所需的免疫细胞适应和哺乳动物胚胎发生。因此，Galectins在胎儿发育和胎盘形成中发挥着重要作用，有助于母婴健康。本文讨论了Galectins在妊娠过程中的表达和作用，重点讨论了近年来发现的母体免疫适应和Galectin-Glycan相互作用。此外，我们还总结了与病理性妊娠相关的半乳糖凝集素指纹图谱，尤其是子痫前期。
Lectin-glycan interactions, in particular those mediated by the galectin family, regulate many processes required for a successful pregnancy. Over the past decades, increasing evidence gathered from in vitro and in vivo experiments indicate that members of the galectin family specifically bind to both intracellular and membrane bound carbohydrate ligands regulating angiogenesis, immune-cell adaptations required to tolerate the fetal semi-allograft and mammalian embryogenesis. Therefore, galectins play important roles in fetal development and placentation contributing to maternal and fetal health. This review discusses the expression and role of galectins during the course of pregnancy, with an emphasis on maternal immune adaptions and galectin-glycan interactions uncovered in the recent years. In addition, we summarize the galectin fingerprints associated with pathological gestation with particular focus on preeclampsia.