Experimental Nipah virus infection in pteropid bats (Pteropus poliocephalus)
Experimental Nipah virus infection in pteropid bats (Pteropus poliocephalus)
复制标题
DOI：
10.1016/j.jcpa.2007.03.002
复制
发表时间：
2007-05-01
影响因子：
0.8
通讯作者：
Daniels, P. W.
中科院分区：
文献类型：
--
作者：
Middleton, D. J.;Morrissy, C. J.;Daniels, P. W.
17灰头果蝠（Pteropus poliocephalus）皮下接种来自致命感染者的尼帕病毒分离株。对照组8只豚鼠腹腔内接种相同的分离株，以确认毒力。8只感染豚鼠中有3只在接种后7-9天出现临床体征。受感染的果蝠发展出亚临床症状。一种感染，其特征是病毒在选定的内脏内短暂存在，间歇性的病毒排泄和血清转化。在受感染蝙蝠的组织内观察到一系列组织病理学变化。尼帕病毒在蝙蝠尿液中排泄，而血清中存在中和抗体。这种间歇性的、低水平的尼帕病毒在蝙蝠尿液中的排泄可能足以维持该病毒在一个物种中的净繁殖价值，在该物种中，有规律的尿液污染皮毛，相互梳理，并且尿滴是环境的一个特征。皇冠版权所有（C）2007由爱思唯尔有限公司出版。保留所有权利。
Seventeen grey-headed fruit bats (Pteropus poliocephalus) were inoculated subcutaneously with an isolate of Nipah virus derived from a fatally infected human. A control group of eight guinea-pigs was inoculated intraperitoneally with the same isolate in order to confirm virulence. Three of eight infected guinea-pigs developed clinical signs 7-9 days post-inoculation. Infected fruit bats developed a subclinical. infection characterized by the transient presence of virus within selected viscera, episodic viral excretion and seroconversion. A range of histopathological changes was observed within the tissues of infected bats. Nipah virus was excreted in bat urine while neutralizing antibody was present in serum. This intermittent, low-level excretion of Nipah virus in the urine of bats may be sufficient to sustain the net reproductive value of the virus in a species where there is regular urine contamination of the fur, mutual grooming, and where urine droplets are a feature of the environment. Crown Copyright (C) 2007 Published by Elsevier Ltd. All rights reserved.