ALZHEIMERS-DISEASE - CELL-SPECIFIC PATHOLOGY ISOLATES THE HIPPOCAMPAL-FORMATION
ALZHEIMERS-DISEASE - CELL-SPECIFIC PATHOLOGY ISOLATES THE HIPPOCAMPAL-FORMATION
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DOI：
10.1126/science.6474172
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发表时间：
1984-01-01
期刊：
影响因子：
56.9
通讯作者：
BARNES, CL
中科院分区：
文献类型：
--
作者：
HYMAN, BT;VANHOESEN, GW;BARNES, CL
对阿尔茨海默病患者颞叶结构的检查揭示了海马结构下托和内嗅皮质第二层和第四层的特定细胞病理模式。受影响的细胞正是那些将海马结构与皮质、基底前脑、丘脑和下丘脑（对记忆至关重要的结构）连接起来的细胞。这种局灶性病理模式将海马结构与其大部分输入和输出隔离开来，并可能导致阿尔茨海默病患者的记忆障碍。
Examination of temporal lobe structures from Alzheimer patients reveals a specific cellular pattern of pathology of the subiculum of the hippocampal formation and layers II and IV of the entorhinal cortex. The affected cells were precisely those that interconnect the hippocampal formation with the association cortices, basal forebrain, thalamus and hypothalamus, structures crucial to memory. This focal pattern of pathology isolates the hippocampal formation from much of its input and output and probably contributes to the memory disorder in Alzheimer patients.