Cocaine-induced reinstatement in rats: evidence for a critical role of cocaine stimulus properties
Cocaine-induced reinstatement in rats: evidence for a critical role of cocaine stimulus properties
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DOI：
10.1007/s00213-008-1083-1
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发表时间：
2008-05-01
影响因子：
3.4
通讯作者：
Cador, Martine
中科院分区：
文献类型：
--
作者：
Keiflin, Ronald;Isingrini, Elsa;Cador, Martine
药物诱导的复吸寻求药物的确切行为性质仍有争议。作为一种激励，药物可以对食欲行为产生一般的促进作用。目的研究可卡因对大鼠食物寻求性恢复的影响。方法实验1中，8组大鼠被训练按下食物小球的杠杆，并经历可卡因（0、5、10、15 mg/kg; i. p.）无论是在操作性条件反射期间，还是在另一个没有食物的环境中4小时后。在实验2中，为了将操作性反应本身的作用与完成性反应分离，两组大鼠在可卡因（10 mg/kg; i. p.）或者在操作性条件反射期间，或者在自由获取食物的交替期间。然后，在两个实验中，食物颗粒被扣留，可卡因注射停止（灭绝）。非依赖性可卡因（10 mg/kg; i. p.）和食物颗粒输送进行了评估。记录自发活动，以探测行为sensitization.Results的表达恢复杠杆按压只在大鼠先前进行了可卡因下的操作性反应。相比之下，食物颗粒输送恢复了独立于大鼠可卡因历史的杠杆按压。运动敏化证明了所有可卡因预暴露大鼠，解离敏化restoration.Conclusions当存在于操作性条件反射，刺激“可卡因”获得条件属性，然后可以促进恢复的熄灭的行为。
Rationale The exact behavioral nature of drug-induced reinstatement of drug seeking is still debated. As an incentive, the drug can have general facilitatory influences on appetitive behaviors. As an interoceptive stimulus, the drug can acquire discriminative properties and control behavior.Objective This study assessed the relative contribution of the incentive versus discriminative properties of cocaine in food-seeking reinstatement.Methods In Experiment 1, eight groups of rats were trained to press a lever for food pellets and experienced cocaine (0, 5, 10, or 15 mg/kg; i.p.), either during the operant conditioning sessions or 4 h after, in another environment without food access. In Experiment 2, to dissociate the role of the operant response per se from the consummatory response, two groups of rats experienced food consumption under cocaine (10 mg/kg; i.p.) either during operant conditioning sessions or during alternate sessions of free access to the food. Then, for both experiments, food pellets were withheld and cocaine injections ceased (extinction). The reinstating effects of noncontingent cocaine (10 mg/kg; i.p.) and food pellet delivery were assessed. Locomotor activity was recorded to probe expression of behavioral sensitization.Results Cocaine reinstated lever pressing only in rats having previously performed the operant responses under cocaine. In contrast, food pellet delivery reinstated lever pressing independently of rats' history with cocaine. Locomotor sensitization was evidenced for all cocaine-pre-exposed rats, dissociating sensitization from reinstatement.Conclusions When present during operant conditioning, the stimulus "cocaine" acquires conditioned properties which can then promote reinstatement of the extinguished behavior.