Are we there yet? Advanced technologies for young children with type 1 diabetes: comment in response to "Type 1 diabetes mellitus management in young children: implementation of current technologies".
Are we there yet? Advanced technologies for young children with type 1 diabetes: comment in response to "Type 1 diabetes mellitus management in young children: implementation of current technologies".
复制标题
我们到了吗？
DOI：
10.1038/s41390-020-0787-8
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发表时间：
2020
影响因子：
3.6
通讯作者：
Artman,Michael
中科院分区：
文献类型：
--
作者：
Clements,MarkA;Patton,SusanaR;McDonough,RyanJ;Artman,Michael
Nevo-Shenker等人的论文1提供了支持在患有1型糖尿病（T1 D）的非常年幼的儿童（<6岁）中使用最近开发的糖尿病自我管理技术的证据。作者所写的具体技术包括连续血糖监测仪（CGMs）、连续皮下胰岛素输注（CSII;又名胰岛素泵）治疗、传感器增强泵（SAP）治疗、预测性低血糖暂停（PLGS）技术和混合闭环（HCL）胰岛素输送。虽然作者为每种技术提供了有希望的早期证据，但研究数量有限，这些研究中幼儿的样本量小，研究中儿童和照顾者的认知和行为表型有限，缺乏专门为幼儿设计的技术，以及持续缺乏良好的专门针对幼儿安全性和有效性设计的纵向随机临床试验仍然存在问题。总的来说，这些限制构成了我们优化T1 D幼儿护理方法的关键差距，并引发了必须探索的多个研究问题。
The paper by Nevo-Shenker et al. 1 presents the evidence available to support use of recently developed diabetes self-management technologies in very young children (< age 6-years-old) with type 1 diabetes (T1D). The specific technologies the authors write about include continuous glucose monitors (CGMs), continuous subcutaneous insulin infusion (CSII; aka insulin pump) therapy, sensoraugmented pump (SAP) therapy, predictive low-glucose suspend (PLGS) technology, and hybrid closed loop (HCL) insulin delivery. While the authors present promising early evidence for each technology, the limited number of studies, the small samples of young children in those studies, the limited cognitive and behavioral phenotyping of the children and caregivers in the studies, the lack of technologies designed specifically for young children, and the continued lack of well-designed longitudinal randomized clinical trials specifically addressing safety and efficacy in young children remain problematic. Collectively, these limitations constitute critical gaps in our approaches to optimizing care for young children with T1D and evoke multiple research questions that must be explored.