Experimental and Theoretical Investigation of the Phase Behavior of Naproxen in Supercritical CO2
Experimental and Theoretical Investigation of the Phase Behavior of Naproxen in Supercritical CO2
复制标题
萘普生在超临界 CO2 中相行为的实验和理论研究
DOI：
10.1021/je800920d
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发表时间：
2009
影响因子：
--
通讯作者：
T. Kraska
中科院分区：
文献类型：
--
作者：
M. Türk;T. Kraska
提出了萘普生在 (313 至 353) K 和压力范围 (15 至 40) MPa 的超临界 CO2 中的新实验溶解度数据。这涵盖了通常使用超临界流体进行的过程（例如超临界流体快速膨胀）的范围。此外，确定了 CO2 + 萘普生系统的固-液-气平衡线为 (0.1 至 30) MPa。溶解度数据通过三种不同的方法进行关联：两种用于密度-溶解度相关性的方法和一种用于压力-溶解度相关性的方法。比较了溶解度相关性所需的不同文献数据和萘普生升华压力的预测。
New experimental solubility data of Naproxen in supercritical CO2 for (313 to 353) K and pressures ranging from (15 to 40) MPa are presented. This covers the range where processes with supercritical fluids such as Rapid Expansion from Supercritical Fluids are typically performed. In addition, the solid−liquid−gas equilibrium line for the CO2 + Naproxen system was determined from (0.1 to 30) MPa. The solubility data are correlated by three different methods: two methods for the density−solubility correlation and one method for the pressure−solubility correlation. Different literature data and predictions of the sublimation pressure of Naproxen, which are required for the solubility correlation, are compared.