Clinical significance of striatal DOPA decarboxylase activity in Parkinson's disease.
Clinical significance of striatal DOPA decarboxylase activity in Parkinson's disease.
复制标题
纹状体多巴脱羧酶活性在帕金森病中的临床意义。
DOI：
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发表时间：
1996
影响因子：
9.3
通讯作者：
D. Eidelberg
中科院分区：
文献类型：
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作者：
T. Ishikawa;Vijay Dhawan;T. Chaly;C. Margouleff;W. Robeson;J. Dahl;Francine S. Mandel;P. Spetsieris;D. Eidelberg
未标记
我们在9名正常志愿者和16名帕金森病患者中进行了氟多巴（FDOPA）的动态PET研究，以研究多巴脱羧酶（DDC）活性测量作为帕金森病过程的有用标志物的适用性。
方法
从3-O-甲基-FDOPA（3OMFD）/PET研究中，我们获得了3OMFD的动力学速率常数的平均群体值（K1M = 0.0400和k2M = 0.0420）。我们应用这些值来计算纹状体DDC活动使用FDOPA房室模型。我们使用动态FDOPA-PET和群体平均K1M和k2M值估计了该组的k3D。然后，我们应用平均群体K1M和k2M值来估计仅使用动态FDOPA-PET研究的新组（6名正常志愿者和11名患者）的k3D（pop）。在所有FDOPA/PET研究中，我们使用图解法计算纹状体摄取速率常数（KiFD），并测量纹状体-枕叶比率（SOR）。
结果
虽然DDC活动已被假定为突触前黑质纹状体多巴胺能功能的精确指标，KiFD和SOR提供了更好的组间歧视比纹状体DDC活动的估计。KiFD和k3D（pop）均与定量疾病严重程度评分显著相关，具有相似的准确度（k3D（pop）和KiFD分别为r = 0.69和0.63; p <0.01）。
结论
虽然估计的纹状体DDC活性与临床残疾相关，但这种措施对早期诊断的有效性很低。我们的结论是，一个简单的估计，如纹状体KiFD是上级的k3D测量大多数临床和研究应用。
UNLABELLED
We performed dynamic PET studies with fluorodopa (FDOPA) in 9 normal volunteers and 16 patients with Parkinson's disease to investigate the applicability of dopa decarboxylase (DDC) activity measurements as useful markers of the parkinsonian disease process.
METHODS
From the 3-O-methyl-FDOPA (3OMFD)/PET studies, we obtained mean population values of the kinetic rate constants for 3OMFD (K1M = 0.0400 and k2M = 0.0420). We applied these values to calculate striatal DDC activity using the FDOPA compartmental model. We estimated k3D in this group using dynamic FDOPA-PET and population mean K1M and k2M values. We then applied the mean population K1M and k2M values to estimate k3D(pop) to a new group (6 normal volunteers and 11 patients) studied only with dynamic FDOPA-PET. In all FDOPA/PET studies, we calculated striatal uptake rate constants (KiFD) using a graphical method and also measured the striato-occipital ratio (SOR).
RESULTS
Although DDC activity has been postulated as a precise indicator of presynaptic nigrostriatal dopaminergic function, KiFD and SOR provided better between-group discrimination than did estimates of striatal DDC activity. KiFD and k3D(pop) both correlated significantly with quantitative disease severity ratings, with a similar degree of accuracy (r = 0.69 and 0.63 for k3D(pop) and KiFD, respectively; p < 0.01).
CONCLUSION
Although estimated striatal DDC activity correlates with clinical disability, this measure is comparably less effective for early diagnosis. We conclude that a simple estimate such as striatal KiFD is superior to k3D measurements for most clinical and research applications.