Targeting Breast Cancer Metastasis.
Targeting Breast Cancer Metastasis.
复制标题
DOI：
10.4137/bcbcr.s25460
复制
发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Mu P
中科院分区：
文献类型：
--
作者：
Jin X;Mu P
转移是乳腺癌相关死亡的主要原因。尽管目前的治疗方法在延长患者生命方面有显著改善，但30-40%的患者最终可能会出现远处复发并死于疾病。因此，更深入地了解转移生物学是开发更好的治疗策略和实现对乳腺癌的持久治疗效果的关键。本文综述了近年来在乳腺癌转移级联反应中发现的各种转移特征，这些特征可能为靶向治疗提供新的途径。
Metastasis is the leading cause of breast cancer-associated deaths. Despite the significant improvement in current therapies in extending patient life, 30–40% of patients may eventually suffer from distant relapse and succumb to the disease. Consequently, a deeper understanding of the metastasis biology is key to developing better treatment strategies and achieving long-lasting therapeutic efficacies against breast cancer. This review covers recent breakthroughs in the discovery of various metastatic traits that contribute to the metastasis cascade of breast cancer, which may provide novel avenues for therapeutic targeting.